Evidence map›Paper›PMID 29158420›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Superoxide Production by NADPH Oxidase Intensifies Macrophage Antiviral Responses during Diabetogenic Coxsackievirus Infection.

Ashley R Burg, Shaonli Das, Lindsey E Padgett, Zachary E Koenig, Hubert M Tse

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. ProtectiveiScience · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. The Role of NADPH Oxidase 2 in Leukocytes.Antioxidants (Basel, Switzerland) · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Perivascular macrophages in health and disease.Nature reviews. Immunology · 2018
    Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ashley R BurgComprehensive Diabetes Center, Department of Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294-2182.
Shaonli DasComprehensive Diabetes Center, Department of Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294-2182.ORCID 0000-0002-5735-5545
Lindsey E PadgettComprehensive Diabetes Center, Department of Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294-2182.ORCID 0000-0002-2925-0076
Zachary E KoenigComprehensive Diabetes Center, Department of Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294-2182.
Hubert M TseComprehensive Diabetes Center, Department of Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294-2182 htse@uab.edu.ORCID 0000-0001-5861-7597
University of Alabama at Birmingham · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
IMMUNOLOGIC DISEASES AND BASIC IMMUNOLOGYT32AI007051 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Laurie Ellen Harrington · 1985 to 2026
$13.1M
ROS Modulation of Innate and Adaptive Immunity in RAP30AR048311 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2001 to 2017
$9.5M
Redox Regulation of Anti-Viral Responses in Type 1 DiabetesR01DK099550 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TSE, HUBERT M · 2014 to 2018
$1.6M
Developing and Improving Institutional Animal ResourcesG20RR025858 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CARTNER, SAMUEL CORBIN · 2009 to 2009
$499k
NCRR NIH HHS G20 RR025858NIAID NIH HHS T32 AI007051NIAMS NIH HHS P30 AR048311NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R01 DK099550
6 · The paper itself

Abstract

Coxsackievirus B infections are suspected environmental triggers of type 1 diabetes (T1D) and macrophage antiviral responses may provide a link to virus-induced T1D. We previously demonstrated an important role for NADPH oxidase (NOX)-derived superoxide production during T1D pathogenesis, as NOX-deficient NOD mice (NOD.

Indexed as

AnimalsApoptosisCells, CulturedChemokinesCoxsackievirus InfectionsDiabetes Mellitus, Type 1Disease Models, AnimalEnterovirusHumansInflammation MediatorsInsulin-Secreting CellsMacrophagesMiceMice, Inbred NODNADPH OxidasesOxidative StressChemokinesInflammation MediatorsNADPH OxidasesRNA, ViralSTAT1 Transcription FactorSuperoxides

Identifiers

PMID29158420
PMCPMC5736405
OpenAlexW2770286924

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.