ArticleProceedings of the National Academy of Sciences of the United States of America2017
Molecular basis of selective resistance of the bumblebee BiNa
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Elucidating the molecular basis of ATP synthase inhibition: A virtual screening framework for next-gen selective acaricides.Science advances · 2026Article
- A unique mechanism of transfluthrin action revealed by mapping its binding sites in the mosquito sodium channel.Insect biochemistry and molecular biology · 2024Article
- Geographical distribution of pyrethroid resistance mutations in Varroa destructor across Türkiye and a European overview.Experimental & applied acarology · 2024Article
- Toward Overcoming Pyrethroid Resistance in Mosquito Control: The Role of Sodium Channel Blocker Insecticides.International journal of molecular sciences · 2023Article
- G3'MTMD3 in the insect GABA receptor subunit, RDL, confers resistance to broflanilide and fluralaner.PLoS genetics · 2023Article
- Characterization of two kdr mutations at predicted pyrethroid receptor site 2 in the sodium channels of Aedes aegypti and Nilaparvata lugens.Insect biochemistry and molecular biology · 2022Article
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- Bioremediation of Agricultural Soils Polluted with Pesticides: A Review.Bioengineering (Basel, Switzerland) · 2021Review
- Distinct functional properties of sodium channel variants are associated with usage of alternative exons in Nilaparvata lugens.Insect biochemistry and molecular biology · 2020Article
- Molecular evidence of sequential evolution of DDT- and pyrethroid-resistant sodium channel in Aedes aegypti.PLoS neglected tropical diseases · 2019Article
- Voltage-gated sodium channels from the bees Apis mellifera and Bombus terrestris are differentially modulated by pyrethroid insecticides.Scientific reports · 2019Article
- Unravelling the Molecular Determinants of Bee Sensitivity to Neonicotinoid Insecticides.Current biology : CB · 2018Article
- Eukaryotic Voltage-Gated Sodium Channels: On Their Origins, Asymmetries, Losses, Diversification and Adaptations.Frontiers in physiology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
Abstract
Insecticides are widely used to control pests in agriculture and insect vectors that transmit human diseases. However, these chemicals can have a negative effect on nontarget, beneficial organisms including bees. Discovery and deployment of selective insecticides is a major mission of modern toxicology and pest management. Pyrethroids exert their toxic action by acting on insect voltage-gated sodium channels. Honeybees and bumblebees are highly sensitive to most pyrethroids, but are resistant to a particular pyrethroid, tau-fluvalinate (τ-FVL). Because of its unique selectivity, τ-FVL is widely used to control not only agricultural pests but also varroa mites, the principal ectoparasite of honeybees. However, the mechanism of bee resistance to τ-FVL largely remains elusive. In this study, we functionally characterized the sodium channel BiNa
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