Evidence map›Paper›PMID 29158412›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Induced

Sanjoy Kumar Khan, Prem Swaroop Yadav, Gene Elliott, Dorothy Zhang Hu, Ruoshi Xu, Yingzi Yang

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019
    Trial
  3. Article
  4. Article
  5. Article
  6. Imprinting and skeletal disorders: lessons from pseudohypoparathyroidism and related disorders.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Genetic characterization of intramuscular myxomas.Pathology oncology research : POR · 2024
    Article
  15. Increased Osteoblast GαJBMR plus · 2023
    Article
  16. Review
  17. Article
  18. Frontiers in endocrinology · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Sanjoy Kumar KhanDepartment of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115.
Prem Swaroop YadavDepartment of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115.
Gene ElliottNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892.
Dorothy Zhang HuDepartment of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA 02115.
Ruoshi XuDepartment of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115.
Yingzi YangDepartment of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115; yingzi_yang@hsdm.harvard.edu.ORCID 0000-0003-3933-887X
Harvard University · USNational Institutes of Health · US

Funding

NHGRI/DIR Embryonic Stem Cell and Transgenic Mouse CoreZICHG200349 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BURGESS, SHAWN M · 2010 to 2025
$23.8M
Gas-Hedgehog signaling in intramembranous bone formation and expansionR01DE025866 · NIDCR · HARVARD MEDICAL SCHOOL · PI Yingzi Yang · 2016 to 2026
$5.3M
Molecular Mechanism of Wnt/Planar Cell Polarity SignalingR01AR070877 · NIAMS · HARVARD MEDICAL SCHOOL · PI YANG, YINGZI · 2017 to 2022
$3.0M
NIAMS NIH HHS R01 AR070877NIDCR NIH HHS R01 DE025866
6 · The paper itself

Abstract

Fibrous dysplasia (FD; Online Mendelian Inheritance in Man no. 174800) is a crippling skeletal disease caused by activating mutations of the

Indexed as

beta CateninCell DifferentiationChromograninsFibrous Dysplasia of BoneGene Expression RegulationGTP-Binding Protein alpha Subunits, GsHumansMesenchymal Stem CellsMutationOsteoblastsSignal TransductionUp-RegulationWnt Proteinsbeta CateninChromograninsGnas protein, mouseGTP-Binding Protein alpha Subunits, GsWnt Proteinsfibrous dysplasiaGnasLGK-974McCune–Albright syndromeWnt/β-catenin

Identifiers

PMID29158412
PMCPMC5776978
OpenAlexW2780177065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.