Evidence map›Paper›PMID 29158391›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Maternal prolactin during late pregnancy is important in generating nurturing behavior in the offspring.

Taku James Sairenji, Jun Ikezawa, Ryosuke Kaneko, Shinnosuke Masuda, Kaoru Uchida, Yurie Takanashi, Hiroko Masuda, Tomoko Sairenji, Izuki Amano, Yusuke Takatsuru and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Perinatal Depression: Current Knowledge.Advances in experimental medicine and biology · 2026
    Review
  5. A head start: The relationship of placental factors to craniofacial and brain development.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Review
  6. Article
  7. Review
  8. Review
  9. Prolactin: structure, receptors, and functions.Reviews in endocrine & metabolic disorders · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. MKK7 deficiency in mature neurons impairs parental behavior in mice.Genes to cells : devoted to molecular & cellular mechanisms · 2021
    Article
  20. Adaptive Resetting of Tuberoinfundibular Dopamine (TIDA) Network Activity during Lactation in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 4 countries.

Taku James SairenjiDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
Jun IkezawaDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
Ryosuke KanekoBioresource Center, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
Shinnosuke MasudaDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
Kaoru UchidaDepartment of Nutrition, Takasaki University of Health and Welfare, Gunma 370-0033, Japan.
Yurie TakanashiDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
Hiroko MasudaDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
Tomoko SairenjiDepartment of Family Medicine, University of Washington School of Medicine, Seattle, WA 98195-6390.
Izuki AmanoDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
Yusuke TakatsuruDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
Kazutoshi SayamaLaboratory of Animal Physiology and Biochemistry, Shizuoka University Graduate School of Agriculture, Shizuoka 422-8529, Japan.
Kaisa HaglundDepartment of Biochemistry, Faculty of Medicine, University of Oslo, Oslo 0379, Norway.
Ivan DikicInstitute of Biochemistry II, Goethe University School of Medicine, Frankfurt am Main 60590, Germany.
Noriyuki KoibuchiDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
Noriaki ShimokawaDepartment of Integrative Physiology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan; shimokawa-n@takasaki-u.ac.jp.
Gunma University · JPTakasaki University of Health and Welfare · JPGoethe University Frankfurt · DEShizuoka University · JPUniversity of Oslo · NOUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although maternal nurturing behavior is extremely important for the preservation of a species, our knowledge of the biological underpinnings of these behaviors is insufficient. Here we show that the degree of a mother's nurturing behavior is regulated by factors present during her own fetal development. We found that Cin85-deficient (

Indexed as

Maternal BehaviorAdaptor Proteins, Signal TransducingAnimalsAnimals, NewbornBehavior, AnimalBrainDopamineEmbryo TransferFemaleGene Expression Regulation, DevelopmentalMiceMice, KnockoutMothersNeoplasm ProteinsNerve Tissue ProteinsPregnancyAdaptor Proteins, Signal TransducingDopamineNeoplasm ProteinsNerve Tissue ProteinsProlactinSh3kbp1 protein, mousefetal brainneglectnurturing behaviorprenatal environmentprolactin

Identifiers

PMID29158391
PMCPMC5724246
OpenAlexW2770656737

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.