Evidence map›Paper›PMID 29158387›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Retrograde inhibition by a specific subset of interpeduncular α5 nicotinic neurons regulates nicotine preference.

Jessica L Ables, Andreas Görlich, Beatriz Antolin-Fontes, Cuidong Wang, Sylvia M Lipford, Michael H Riad, Jing Ren, Fei Hu, Minmin Luo, Paul J Kenny and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 62 citations in OpenAlex.

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  15. The many enigmas of nicotine.Advances in pharmacology (San Diego, Calif.) · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Impact of the gut microbiome on nicotine's motivational effects and glial cells in the ventral tegmental area in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Jessica L AblesLaboratory of Molecular Biology, The Rockefeller University, New York, NY 10065.
Andreas GörlichLaboratory of Molecular Biology, The Rockefeller University, New York, NY 10065.
Beatriz Antolin-FontesLaboratory of Molecular Biology, The Rockefeller University, New York, NY 10065.
Cuidong WangLaboratory of Molecular Biology, The Rockefeller University, New York, NY 10065.
Sylvia M LipfordLaboratory of Molecular Biology, The Rockefeller University, New York, NY 10065.
Michael H RiadLaboratory of Molecular Biology, The Rockefeller University, New York, NY 10065.
Jing RenNational Institute of Biological Sciences, Beijing 102206, China.
Fei HuNational Institute of Biological Sciences, Beijing 102206, China.
Minmin LuoNational Institute of Biological Sciences, Beijing 102206, China.
Paul J KennyDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Nathaniel HeintzLaboratory of Molecular Biology, The Rockefeller University, New York, NY 10065; heintz@rockefeller.edu iibanez@rockefeller.edu.
Ines Ibañez-TallonLaboratory of Molecular Biology, The Rockefeller University, New York, NY 10065; heintz@rockefeller.edu iibanez@rockefeller.edu.ORCID 0000-0002-4908-4626
Rockefeller University · USNational Institute of Biological Sciences, Beijing · CNHoward Hughes Medical Institute · USIcahn School of Medicine at Mount Sinai · US

Funding

RESEARCH SUPPORT CORE 4P30DA035756 · NIDA · ROCKEFELLER UNIVERSITY · PI HEINTZ, NATHANIEL · 2013 to 2017
$6.7M
Mechanisms of nicotine reinforcement in miceR01DA020686 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI KENNY, PAUL J. · 2007 to 2016
$3.6M
Howard Hughes Medical InstituteNIDA NIH HHS P30 DA035756NIDA NIH HHS R01 DA020686
6 · The paper itself

Abstract

Repeated exposure to drugs of abuse can produce adaptive changes that lead to the establishment of dependence. It has been shown that allelic variation in the α5 nicotinic acetylcholine receptor (nAChR) gene

Indexed as

AnimalsFemaleGene Expression ProfilingGene Expression RegulationHabenulaInterpeduncular NucleusMaleMiceMice, TransgenicNeuronsNeurotransmitter AgentsNicotineNitric OxideNitric Oxide Synthase Type IProtein BiosynthesisProtein IsoformsCHRNA5 protein, mouseNeurotransmitter AgentsNicotineNitric OxideNitric Oxide Synthase Type INos1 protein, mouseProtein IsoformsReceptors, NicotinicRNA, Small InterferingSomatostatininterpeduncular nucleusnicotineretrogradeα5 nicotinic

Identifiers

PMID29158387
PMCPMC5724287
OpenAlexW2769350629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.