Evidence map›Paper›PMID 29158353›Full record

ArticleHypertension (Dallas, Tex. : 1979)2018

Blood Pressure Control by a Secreted FGFBP1 (Fibroblast Growth Factor-Binding Protein).

Elena Tassi, En Yin Lai, Lingli Li, Glenn Solis, Yifan Chen, William E Kietzman, Patricio E Ray, Anna T Riegel, William J Welch, Christopher S Wilcox and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Genome-Wide Meta-Analysis of Blood Pressure Response to βJournal of the American Heart Association · 2019
    Pooled it
  2. Chemistry and Biological Activity of 11Molecules (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Plasma human growth cytokines in children with vasovagal syncope.Frontiers in cardiovascular medicine · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Antihypertensive activity of a new c-Jun N-terminal kinase inhibitor in spontaneously hypertensive rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2020
    Article
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Elena TassiFrom the Lombardi Cancer Center (E.T., W.E.K., A.T.R., A.W.) and Division of Nephrology and Hypertension (E.Y.L., L.L., G.S., Y.C., W.J.W., C.S.W.), Georgetown University, Washington, DC; Department of Physiology, Zhejiang University, Hangzhou, China (E.Y.L.); and Children's National Medical Center, George Washington University, DC (P.E.R.).
En Yin LaiFrom the Lombardi Cancer Center (E.T., W.E.K., A.T.R., A.W.) and Division of Nephrology and Hypertension (E.Y.L., L.L., G.S., Y.C., W.J.W., C.S.W.), Georgetown University, Washington, DC; Department of Physiology, Zhejiang University, Hangzhou, China (E.Y.L.); and Children's National Medical Center, George Washington University, DC (P.E.R.).
Lingli LiFrom the Lombardi Cancer Center (E.T., W.E.K., A.T.R., A.W.) and Division of Nephrology and Hypertension (E.Y.L., L.L., G.S., Y.C., W.J.W., C.S.W.), Georgetown University, Washington, DC; Department of Physiology, Zhejiang University, Hangzhou, China (E.Y.L.); and Children's National Medical Center, George Washington University, DC (P.E.R.).
Glenn SolisFrom the Lombardi Cancer Center (E.T., W.E.K., A.T.R., A.W.) and Division of Nephrology and Hypertension (E.Y.L., L.L., G.S., Y.C., W.J.W., C.S.W.), Georgetown University, Washington, DC; Department of Physiology, Zhejiang University, Hangzhou, China (E.Y.L.); and Children's National Medical Center, George Washington University, DC (P.E.R.).
Yifan ChenFrom the Lombardi Cancer Center (E.T., W.E.K., A.T.R., A.W.) and Division of Nephrology and Hypertension (E.Y.L., L.L., G.S., Y.C., W.J.W., C.S.W.), Georgetown University, Washington, DC; Department of Physiology, Zhejiang University, Hangzhou, China (E.Y.L.); and Children's National Medical Center, George Washington University, DC (P.E.R.).
William E KietzmanFrom the Lombardi Cancer Center (E.T., W.E.K., A.T.R., A.W.) and Division of Nephrology and Hypertension (E.Y.L., L.L., G.S., Y.C., W.J.W., C.S.W.), Georgetown University, Washington, DC; Department of Physiology, Zhejiang University, Hangzhou, China (E.Y.L.); and Children's National Medical Center, George Washington University, DC (P.E.R.).
Patricio E RayFrom the Lombardi Cancer Center (E.T., W.E.K., A.T.R., A.W.) and Division of Nephrology and Hypertension (E.Y.L., L.L., G.S., Y.C., W.J.W., C.S.W.), Georgetown University, Washington, DC; Department of Physiology, Zhejiang University, Hangzhou, China (E.Y.L.); and Children's National Medical Center, George Washington University, DC (P.E.R.).
Anna T RiegelFrom the Lombardi Cancer Center (E.T., W.E.K., A.T.R., A.W.) and Division of Nephrology and Hypertension (E.Y.L., L.L., G.S., Y.C., W.J.W., C.S.W.), Georgetown University, Washington, DC; Department of Physiology, Zhejiang University, Hangzhou, China (E.Y.L.); and Children's National Medical Center, George Washington University, DC (P.E.R.).
William J WelchFrom the Lombardi Cancer Center (E.T., W.E.K., A.T.R., A.W.) and Division of Nephrology and Hypertension (E.Y.L., L.L., G.S., Y.C., W.J.W., C.S.W.), Georgetown University, Washington, DC; Department of Physiology, Zhejiang University, Hangzhou, China (E.Y.L.); and Children's National Medical Center, George Washington University, DC (P.E.R.).
Christopher S WilcoxFrom the Lombardi Cancer Center (E.T., W.E.K., A.T.R., A.W.) and Division of Nephrology and Hypertension (E.Y.L., L.L., G.S., Y.C., W.J.W., C.S.W.), Georgetown University, Washington, DC; Department of Physiology, Zhejiang University, Hangzhou, China (E.Y.L.); and Children's National Medical Center, George Washington University, DC (P.E.R.).
Anton WellsteinFrom the Lombardi Cancer Center (E.T., W.E.K., A.T.R., A.W.) and Division of Nephrology and Hypertension (E.Y.L., L.L., G.S., Y.C., W.J.W., C.S.W.), Georgetown University, Washington, DC; Department of Physiology, Zhejiang University, Hangzhou, China (E.Y.L.); and Children's National Medical Center, George Washington University, DC (P.E.R.). anton.wellstein@georgetown.edu.
Zhejiang University · CN

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI STEPHEN W BYERS · 1990 to 2026
$71.5M
Renal Vascular Oxidative Stress in HypertensionP01HL068686 · NHLBI · GEORGETOWN UNIVERSITY · PI JOSE, PEDRO A., SANDBERG, KATHRYN L · 2001 to 2017
$28.8M
TRAINING GRANT IN TUMOR BIOLOGYT32CA009686 · NCI · GEORGETOWN UNIVERSITY · PI ANNA Tate RIEGEL, DAVID J ROBBINS · 1996 to 2026
$10.8M
Role of bFGF low affinity receptors in childhood HIVANR01DK049419 · NIDDK · UNIVERSITY OF VIRGINIA · PI PATRICIO E. RAY · 1994 to 2026
$7.4M
REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANER37DK036079 · NIDDK · GEORGETOWN UNIVERSITY · PI WILCOX, CHRISTOPHER S · 2003 to 2012
$5.2M
NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUSR01DK049870 · NIDDK · GEORGETOWN UNIVERSITY · PI WILCOX, CHRISTOPHER S · 1994 to 2014
$4.6M
Role of heparin binding growth factors in vascular leakage and fatal bleedingR01HL102497 · NHLBI · UNIVERSITY OF VIRGINIA · PI RAY, PATRICIO E. · 2009 to 2018
$3.4M
BIOLOGY AND PATHOLOGY OF A MODULATOR OF FGFR01CA071508 · NCI · GEORGETOWN UNIVERSITY · PI WELLSTEIN, ANTON · 1997 to 2010
$2.9M
Pathogenesis of chronic renal injury and hypertension in HIV-infected childrenR01DK108368 · NIDDK · UNIVERSITY OF VIRGINIA · PI RAY, PATRICIO E. · 2015 to 2019
$1.5M
Regulation of Renal Function and BP by ThromboxaneR01DK109272 · NIDDK · GEORGETOWN UNIVERSITY · PI WELCH, WILLIAM J, WILCOX, CHRISTOPHER S · 2016 to 2019
$1.4M
REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANER01DK036079 · NIDDK · UNIVERSITY OF FLORIDA · PI WILCOX, CHRISTOPHER S · 1986 to 2002
$830k
NCI NIH HHS P30 CA051008NCI NIH HHS R01 CA071508NCI NIH HHS T32 CA009686NHLBI NIH HHS P01 HL068686NHLBI NIH HHS R01 HL102497NIDDK NIH HHS R01 DK036079NIDDK NIH HHS R01 DK049419NIDDK NIH HHS R01 DK049870NIDDK NIH HHS R01 DK108368NIDDK NIH HHS R01 DK109272NIDDK NIH HHS R37 DK036079
6 · The paper itself

Abstract

Fibroblast growth factors (FGFs) participate in organ development and tissue maintenance, as well as the control of vascular function. The paracrine-acting FGFs are stored in the extracellular matrix, and their release is controlled by a secreted FGF-binding protein (FGF-BP, FGFBP1, and BP1) that modulates FGF receptor signaling. A genetic polymorphism in the human

Indexed as

Blood PressureHypertensionVasoconstrictionAngiotensin II Type 1 Receptor BlockersAnimalsBenzimidazolesBiphenyl CompoundsCarrier ProteinsCyclic N-OxidesDisease Models, AnimalFibroblast Growth FactorsHumansIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsMiceMice, TransgenicAngiotensin II Type 1 Receptor BlockersBenzimidazolesBiphenyl CompoundscandesartanCarrier ProteinsCyclic N-OxidesFGFBP1 protein, humanFgfbp1 protein, mouseFibroblast Growth FactorsIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsMitogen-Activated Protein KinasesProtein Synthesis InhibitorsSpin LabelstempolTetrazolesangiotensin IIblood pressurefibroblast growth factorreactive oxygen speciesvascular resistance

Identifiers

PMID29158353
PMCPMC5730494
OpenAlexW2770017595

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.