ReviewReproduction (Cambridge, England)2017
Intracytoplasmic sperm injection: state of the art in humans.
Review in Reproduction (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 145 citations in OpenAlex.
- Reproductive tract and follicular fluid microbiota and probiotic interventions in IVF/ICSI outcomes: a systematic review.BMC pregnancy and childbirth · 2026Pooled it
- Intelligence, motoric and psychological outcomes in children from different ART treatments: a systematic review and meta-analysis.Journal of neurodevelopmental disorders · 2023Pooled it
- Risk of neurodevelopmental disorders in children born from different ART treatments: a systematic review and meta-analysis.Journal of neurodevelopmental disorders · 2020Pooled it
- Microfluidic sperm selection versus density gradient centrifugation in ICSI cycles with abnormal semen parameters: a randomized sibling-oocyte study.Scientific reports · 2026Trial
- Trial
- Insights into The Outcomes of Artificial Oocyte Activation: A Retrospecive Analysis of 1,300 Couples Undergoing Intracytoplasmic Sperm Injection.International journal of fertility & sterility · 2026Article
- Protocol for in vivo transfection of mRNA-encapsulated lipid nanoparticles in mouse testis.STAR protocols · 2026Article
- Conventional in vitro fertilization at the age of fourtiesJournal of the Turkish German Gynecological Association · 2026Article
- Article
- Lived experiences of assisted reproductive technology treatment among men with azoospermia in Taiwan: a qualitative study.Reproductive health · 2026Article
- How Early-Life Programming During Embryogenesis Imprints Cellular Memory.International journal of molecular sciences · 2025Review
- PLCZ1 gene mutation leads to fertilization disorder: a case report.JBRA assisted reproduction · 2025Article
- Factors affecting the intracytoplasmic sperm cell injection outcomes: A meta-analysis of porcine studies.Journal of advanced research · 2025Article
- Stage-Resolved Phosphoproteomic Landscape of Mouse Spermiogenesis Reveals Key Kinase Signaling in Sperm Morphogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Review
- The Pre-Catching Sperm Technique Increases the Efficiency of the Intracytoplasmic Sperm Injection Method by Improving Fertilization and Blastocyst Formation Rates.Journal of clinical medicine · 2025Article
- Identification of nonfunctional CABS1 causing fertilization failure and male infertility in humans: a case report.Journal of assisted reproduction and genetics · 2025Article
- Male gamete copies to characterize genome inheritance and generate progenies.Scientific reports · 2025Article
- Study Protocol: Comparison of Clinical Pregnancy Outcomes of Intracytoplasmic Sperm Injection (ICSI) Using Testicular and Ejaculated Spermatozoa in Male Patients with High DNA Fragmentation.Journal of pharmacy & bioallied sciences · 2025Article
- An assessment of total antioxidant and oxidant parameters and their correlation with embryo quality in in-vitro fertilization patients.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among infertile couples, 25% involve both male and female factors, while male factor alone accounts for another 25% due to oligo-, astheno-, teratozoospermia, a combination of the three, or even a complete absence of sperm cells in the ejaculate and can lead to a poor prognosis even with the help of assisted reproductive technology (ART). Intracytoplasmic sperm injection (ICSI) has been with us now for a quarter of a century and in spite of the controversy generated since its inception, it remains in the forefront of the techniques utilized in ART. The development of ICSI in 1992 has drastically decreased the impact of male factor, resulting in millions of pregnancies worldwide for couples who, without ICSI, would have had little chance of having their own biological child. This review focuses on the state of the art of ICSI regarding utility of bioassays that evaluate male factor infertility beyond the standard semen analysis and describes the current application and advances in regard to ICSI, particularly the genetic and epigenetic characteristics of spermatozoa and their impact on reproductive outcome.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.