Evidence map›Paper›PMID 29158349›Full record

ArticleEMBO reports2018

Regulatory T cells are expanded by Teriparatide treatment in humans and mediate intermittent PTH-induced bone anabolism in mice.

Mingcan Yu, Patrizia D'Amelio, Abdul Malik Tyagi, Chiara Vaccaro, Jau-Yi Li, Emory Hsu, Ilaria Buondonno, Francesca Sassi, Jonathan Adams, M Neale Weitzmann and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Mingcan YuDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.
Patrizia D'AmelioGerontology Section, Department of Medical Sciences, University of Torino, Torino, Italy.
Abdul Malik TyagiDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.
Chiara VaccaroDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.
Jau-Yi LiDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.
Emory HsuDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.
Ilaria BuondonnoGerontology Section, Department of Medical Sciences, University of Torino, Torino, Italy.
Francesca SassiGerontology Section, Department of Medical Sciences, University of Torino, Torino, Italy.
Jonathan AdamsDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.
M Neale WeitzmannDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.
Richard DiPaoloDepartment of Molecular Microbiology & Immunology, Saint Louis University School of Medicine, St. Louis, MO, USA.
Roberto PacificiDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA roberto.pacifici@emory.edu.ORCID 0000-0001-6077-8250
Emory University · USUniversity of Turin · ITSaint Louis University · US

Funding

T CELLS AND PTH INDUCED BONE LOSSR01AR054625 · NIAMS · EMORY UNIVERSITY · PI PACIFICI, ROBERTO · 2007 to 2016
$3.3M
Accelerated Bone Loss in Aging HIV-infected IndividualsR01AR068157 · NIAMS · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, WEITZMANN, MERVYN NEALE · 2015 to 2019
$3.3M
IL-4, a key regulator of bone turnover in HIV and ARTR01AR070091 · NIAMS · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, WEITZMANN, MERVYN NEALE · 2016 to 2020
$3.2M
Bone Loss and Immune Reconstitution in HIV/AIDSR01AG040013 · NIA · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, WEITZMANN, MERVYN NEALE · 2011 to 2015
$2.8M
Research Training in Translational Gastroenterology and HepatologyT32DK108735 · NIDDK · EMORY UNIVERSITY · PI SUBRA KUGATHASAN · 2016 to 2026
$2.6M
Th17 cells and Tregs determine the catabolic and anabolic effects of PTH in boneR01DK108842 · NIDDK · EMORY UNIVERSITY · PI PACIFICI, ROBERTO · 2016 to 2018
$1.2M
In Vivo MicroCT ScannerS10RR028009 · NCRR · EMORY UNIVERSITY · PI PACIFICI, ROBERTO · 2010 to 2010
$494k
The contribution of T cells to the anabolic activity of PTH in boneK01AR061453 · NIAMS · EMORY UNIVERSITY · PI LI, JAU-YI · 2012 to 2015
$382k
Immune Regulation of Bone HomeostasisI01BX000105 · VA · VETERANS HEALTH ADMINISTRATION · PI WEITZMANN, MERVYN NEALE · 2009 to 2022
–
BLRD VA I01 BX000105NCRR NIH HHS S10 RR028009NIAMS NIH HHS K01 AR061453NIAMS NIH HHS R01 AR054625NIAMS NIH HHS R01 AR068157NIAMS NIH HHS R01 AR070091NIA NIH HHS R01 AG040013NIDDK NIH HHS R01 DK108842NIDDK NIH HHS T32 DK108735
6 · The paper itself

Abstract

Teriparatide is a bone anabolic treatment for osteoporosis, modeled in animals by intermittent PTH (iPTH) administration, but the cellular and molecular mechanisms of action of iPTH are largely unknown. Here, we show that Teriparatide and iPTH cause a ~two-threefold increase in the number of regulatory T cells (Tregs) in humans and mice. Attesting

Indexed as

AgedAnimalsBiomarkersBone Density Conservation AgentsCalciumCalcium-Regulating Hormones and AgentsCollagen Type ICore Binding Factor Alpha 1 SubunitDisease Models, AnimalFemaleGene ExpressionHumansIntegrin-Binding SialoproteinLymphocyte CountMiceOsteocalcin25-hydroxyvitamin DBiomarkersBone Density Conservation AgentsCalciumCalcium-Regulating Hormones and AgentsCollagen Type ICore Binding Factor Alpha 1 SubunitIntegrin-Binding SialoproteinOsteocalcinRunx2 protein, mouseSp7 protein, mouseSp7 Transcription FactorTeriparatideTransforming Growth Factor betaVitamin Dbonebone formationparathyroid hormoneregulatory T cells

Identifiers

PMID29158349
PMCPMC5757282
OpenAlexW2768741494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.