Evidence map›Paper›PMID 29158323›Full record

ArticleBiology open2017

FGF8 morphogen gradients are differentially regulated by heparan sulphotransferases Hs2st and Hs6st1 in the developing brain.

Wai-Kit Chan, David J Price, Thomas Pratt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Wai-Kit ChanCentre for Integrative Physiology, Edinburgh Medical School Biomedical Sciences, The University of Edinburgh, Edinburgh, EH8 9XD, UK.ORCID http://orcid.org/0000-0002-6661-0640
David J PriceCentre for Integrative Physiology, Edinburgh Medical School Biomedical Sciences, The University of Edinburgh, Edinburgh, EH8 9XD, UK.ORCID http://orcid.org/0000-0002-9728-9992
Thomas PrattCentre for Integrative Physiology, Edinburgh Medical School Biomedical Sciences, The University of Edinburgh, Edinburgh, EH8 9XD, UK t.pratt@ed.ac.uk.ORCID http://orcid.org/0000-0003-4042-4409
University of Edinburgh · GB

Funding

Medical Research Council G0701460
6 · The paper itself

Abstract

Fibroblast growth factor (FGF) morphogen signalling through the evolutionarily ancient extracellular signalling-regulated kinase/mitogen activated protein kinase (ERK/MAPK) pathway recurs in many neural and non-neural developmental contexts, and understanding the mechanisms that regulate FGF/ERK function are correspondingly important. The glycosaminoglycan heparan sulphate (HS) binds to FGFs and exists in an enormous number of differentially sulphated forms produced by the action of HS modifying enzymes, and so has the potential to present an extremely large amount of information in FGF/ERK signalling. Although there have been many studies demonstrating that HS is an important regulator of FGF function, experimental evidence on the role of the different HS modifying enzymes on FGF gradient formation has been lacking until now. We challenged

Indexed as

ErkFibroblast growth factorsHeparan sulphotransferaseHs2stHs6st1MapkMouseNeural developmentTelencephalon

Identifiers

PMID29158323
PMCPMC5769653
OpenAlexW2769006934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.