ArticleAntimicrobial agents and chemotherapy2018
A Simplified Derivative of Human Defensin 5 with Potent and Efficient Activity against Multidrug-Resistant Acinetobacter baumannii.
Open access · bronzeAbstract read
In one paragraph
Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Evaluation of LLM-generated peptide as foundation template for discovery of effective encrypted AMPs against clinical superbugs.Microbiology spectrum · 2025Article
- AbOmpA in Acinetobacter baumannii: exploring virulence mechanisms of outer membrane-integrated and outer membrane vesicle-associated AbOmpA and developing anti-infective agents targeting AbOmpA.Journal of biomedical science · 2025Review
- Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning.eLife · 2025Article
- Multidrug resistantCurrent research in microbial sciences · 2025Review
- Synergistic collaboration between AMPs and non-direct antimicrobial cationic peptides.Nature communications · 2024Article
- Application of a derivative of human defensin 5 to treat ionizing radiation-induced enterogenic infection.Journal of radiation research · 2024Article
- An Update on the Therapeutic Potential of Antimicrobial Peptides againstPharmaceuticals (Basel, Switzerland) · 2023Review
- Molecular dynamics simulations of human α-defensin 5 (HD5) crossing gram-negative bacterial membrane.PloS one · 2023Article
- Antimicrobial Peptide Cec4 Eradicates Multidrug-ResistantDrug design, development and therapy · 2023Article
- Article
- A Novel Antimicrobial Peptide Sp-LECin with Broad-Spectrum Antimicrobial Activity and Anti-International journal of molecular sciences · 2022Article
- Mammals' humoral immune proteins and peptides targeting the bacterial envelope: from natural protection to therapeutic applications against multidrug-resistant Gram-negatives.Biological reviews of the Cambridge Philosophical Society · 2022Review
- Human defensin-inspired discovery of peptidomimetic antibiotics.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Selenium nanoparticles alleviate ischemia reperfusion injury-induced acute kidney injury by modulating GPx-1/NLRP3/Caspase-1 pathway.Theranostics · 2022Article
- How to Combat Gram-Negative Bacteria Using Antimicrobial Peptides: A Challenge or an Unattainable Goal?Antibiotics (Basel, Switzerland) · 2021Review
- Evaluation of the Binding Mechanism of Human Defensin 5 in a Bacterial Membrane: A Simulation Study.International journal of molecular sciences · 2021Article
- An angiotensin-converting enzyme-2-derived heptapeptide GK-7 for SARS-CoV-2 spike blockade.Peptides · 2021Article
- The penetration of human defensin 5 (HD5) through bacterial outer membrane: simulation studies.Journal of molecular modeling · 2021Article
- Antimicrobial and Anti-Biofilm Peptide Octominin for Controlling Multidrug-ResistantInternational journal of molecular sciences · 2021Article
- Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection.Journal of biomedical science · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 1 institution in 1 country.
Cheng WangState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Shapingba, Chongqing, People's Republic of China.ORCID 0000-0001-5850-4533
Gaomei ZhaoState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Shapingba, Chongqing, People's Republic of China.
Song WangState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Shapingba, Chongqing, People's Republic of China.
Yin ChenState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Shapingba, Chongqing, People's Republic of China.
Yali GongInstitute of Burn Research, Southwest Hospital, Third Military Medical University, Shapingba, Chongqing, People's Republic of China.
Shilei ChenState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Shapingba, Chongqing, People's Republic of China.
Yang XuState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Shapingba, Chongqing, People's Republic of China.
Mengjia HuState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Shapingba, Chongqing, People's Republic of China.
Xinmiao WangState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Shapingba, Chongqing, People's Republic of China.
Hao ZengState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Shapingba, Chongqing, People's Republic of China.
Aiping WangState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Shapingba, Chongqing, People's Republic of China.
Dengqun LiuState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Shapingba, Chongqing, People's Republic of China.
Yongping SuState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Shapingba, Chongqing, People's Republic of China.
Tianmin ChengState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Shapingba, Chongqing, People's Republic of China.
Fang ChenState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Shapingba, Chongqing, People's Republic of China chenfang83@126.com wangjunping@tmmu.edu.cn.
Junping WangState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Shapingba, Chongqing, People's Republic of China chenfang83@126.com wangjunping@tmmu.edu.cn.
Army Medical University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increasing incidence of multidrug-resistant
Indexed as
Gene Expression Regulation, BacterialAcinetobacter baumanniiAcinetobacter Infectionsalpha-DefensinsAnimalsAnti-Bacterial AgentsBacterial Outer Membrane ProteinsBacterial ProteinsCatalaseDisease Models, AnimalDose-Response Relationship, DrugFemaleHumansLipid AMiceMice, Inbred BALB Calpha-DefensinsAnti-Bacterial AgentsBacterial Outer Membrane ProteinsBacterial ProteinsCatalaseDEFA5 protein, humanLipid AOMPA outer membrane proteinsProtein IsoformsReactive Oxygen SpeciesSuperoxide DismutaseAcinetobacter baumanniidefensinmembrane penetrationouter membrane protein Areactive oxygen species
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.