Evidence map›Paper›PMID 29158256›Full record

ArticleThe Journal of biological chemistry2018

Heart failure-induced activation of phospholipase iPLA

Sung Ho Moon, Xinping Liu, Ari M Cedars, Kui Yang, Michael A Kiebish, Susan M Joseph, John Kelley, Christopher M Jenkins, Richard W Gross

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
  2. Article
  3. Molecular therapy. Oncology · 2025
    Article
  4. Review
  5. Article
  6. Effects of sEH inhibition on the eicosanoid and cytokine storms in SARS-CoV-2-infected mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  7. Article
  8. Article
  9. The PNPLA family of enzymes: characterisation and biological role.Arhiv za higijenu rada i toksikologiju · 2023
    Article
  10. The Link between Prostanoids and Cardiovascular Diseases.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023
    Article
  13. Review
  14. Review
  15. Review
  16. Mitochondrial CaJournal of molecular and cellular cardiology · 2021
    Review
  17. Article
  18. Review
  19. Updating Phospholipase ABiomolecules · 2020
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sung Ho MoonDivision of Bioorganic Chemistry and Molecular Pharmacology, the Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
Xinping LiuDivision of Bioorganic Chemistry and Molecular Pharmacology, the Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
Ari M CedarsDivision of Bioorganic Chemistry and Molecular Pharmacology, the Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
Kui YangDivision of Bioorganic Chemistry and Molecular Pharmacology, the Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
Michael A KiebishDivision of Bioorganic Chemistry and Molecular Pharmacology, the Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
Susan M JosephCardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
John KelleyDivision of Bioorganic Chemistry and Molecular Pharmacology, the Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
Christopher M JenkinsDivision of Bioorganic Chemistry and Molecular Pharmacology, the Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
Richard W GrossDivision of Bioorganic Chemistry and Molecular Pharmacology, the Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110; Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110; Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110; Department of Chemistry, Washington University, St. Louis, Missouri 63130. Electronic address: rgross@wustl.edu.
Washington University in St. Louis · US

Funding

REGULATION OF MYOCARDIAL PHOSPHOLIPASES AND LIPASES IN DIABETIC MYOCARDIUMR01HL118639 · NHLBI · WASHINGTON UNIVERSITY · PI GROSS, RICHARD W · 2013 to 2025
$9.1M
NOVEL LIPID 2ND MESSENGERS REGULATING BIOENERGETICS AND SIGNALING IN HUMAN MYOCARDIUMR01HL133178 · NHLBI · WASHINGTON UNIVERSITY · PI GROSS, RICHARD W · 2016 to 2024
$3.8M
NHLBI NIH HHS R01 HL118639NHLBI NIH HHS R01 HL133178
6 · The paper itself

Abstract

Congestive heart failure typically arises from cardiac myocyte necrosis/apoptosis, associated with the pathological opening of the mitochondrial permeability transition pore (mPTP). mPTP opening decreases the mitochondrial membrane potential leading to the activation of Ca

Indexed as

Amino Acid SequenceCalciumCalcium ChannelsGroup VI Phospholipases A2Heart FailureHumansHydroxyeicosatetraenoic AcidsMembrane Potential, MitochondrialMitochondria, HeartMitochondrial MembranesMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreMyocardiumPermeabilityPhospholipases A2CalciumCalcium ChannelsGroup VI Phospholipases A2Hydroxyeicosatetraenoic AcidsMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PorePhospholipases A2PLA2G6 protein, humancytochrome P-450eicosanoidheart failurelipoxygenasemitochondrial permeability transition pore (mPTP)phospholipase

Identifiers

PMID29158256
PMCPMC5766913
OpenAlexW2769410191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.