Evidence map›Paper›PMID 29158241›Full record

ArticleJournal of bacteriology2018

Polyphosphate Kinase Antagonizes Virulence Gene Expression in Francisella tularensis.

Amy E Rohlfing, Kathryn M Ramsey, Simon L Dove

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. [A fluorometric method for direct detection of inorganic polyphosphate in enterohemorrhagicNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Amy E RohlfingDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Kathryn M RamseyDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Simon L DoveDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA simon.dove@childrens.harvard.edu.
Boston Children's Hospital · USHarvard University · US

Funding

Pediatric Infectious Diseases Research TrainingT32HD055148 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI WESSELS, MICHAEL R · 2008 to 2018
$2.7M
Control of virulence gene expression in Francisella tularensisR01AI081693 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI DOVE, SIMON L · 2010 to 2014
$2.1M
Control of virulence gene expression in Francisella tularensisR56AI081693 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI DOVE, SIMON L · 2018 to 2018
$489k
NIAID NIH HHS R01 AI081693NIAID NIH HHS R56 AI081693NICHD NIH HHS T32 HD055148
6 · The paper itself

Abstract

The alarmone ppGpp is a critical regulator of virulence gene expression in

Indexed as

Gene Expression Regulation, BacterialAnimalsBacterial ProteinsCell LineDNA-Directed RNA PolymerasesEscherichia coliFrancisella tularensisGenomic IslandsMacrophagesMicePhosphotransferases (Phosphate Group Acceptor)PolyphosphatesProtein BindingTranscription FactorsTwo-Hybrid System TechniquesVirulenceBacterial ProteinsDNA-Directed RNA PolymerasesPhosphotransferases (Phosphate Group Acceptor)polyphosphate kinasePolyphosphatesTranscription Factorsgene regulationMglAppGppSspA

Identifiers

PMID29158241
PMCPMC5763045
OpenAlexW2770662773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.