ArticleJournal of molecular biology2018
The Developmental Switch in Bacteriophage λ: A Critical Role of the Cro Protein.
Article in Journal of molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Genetic engineering of cyanophages for harmful cyanobacterial bloom treatment-A mini review.Synthetic and systems biotechnology · 2027Review
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- Review of the Arbitrium (ARM) System: Molecular Mechanisms, Ecological Impacts, and Applications in Phage-Host Communication.Microorganisms · 2025Review
- Comprehensive Genomic Analysis ofMicroorganisms · 2025Article
- The Role of Quorum Sensing in Phage Lifecycle Decision: A Switch Between Lytic and Lysogenic Pathways.Viruses · 2025Review
- Fine-tuned spatiotemporal dynamics of DNA replication during phage lambda infection.Journal of virology · 2024Article
- Insight into the Mechanism of Lysogeny Control of phiCDKH01 Bacteriophage Infecting Clinical Isolate ofInternational journal of molecular sciences · 2024Article
- The crystal structure of bacteriophage λ RexA provides novel insights into the DNA binding properties of Rex-like phage exclusion proteins.Nucleic acids research · 2024Article
- Lethal perturbation of an Escherichia coli regulatory network is triggered by a restriction-modification system's regulator and can be mitigated by excision of the cryptic prophage Rac.Nucleic acids research · 2024Article
- Article
- Distribution, inducibility, and characterisation of prophages in Latilactobacillus sakei.BMC microbiology · 2022Article
- Alternating lysis and lysogeny is a winning strategy in bacteriophages due to Parrondo's paradox.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Bacteriophage λ RexA and RexB functions assist the transition from lysogeny to lytic growth.Molecular microbiology · 2021Article
- Clostridioides difficile phage biology and application.FEMS microbiology reviews · 2021Review
- Phage-Encoded Endolysins.Antibiotics (Basel, Switzerland) · 2021Review
- Bacteriophage and the Innate Immune System: Access and Signaling.Microorganisms · 2019Review
- Close Encounters of Three Kinds: Bacteriophages, Commensal Bacteria, and Host Immunity.Trends in microbiology · 2018Review
- Ectopic Expression of themSphere · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Bacteriophage λ of Escherichia coli has two alternative life cycles after infection-host survival with lysogen formation, or host lysis and phage production. In a lysogen, CI represses the two lytic promoters, pR and pL, and activates its own transcription from the auto-regulated pRM promoter. During induction from the lysogenic to lytic state, CI is inactivated, and the two lytic promoters are de-repressed allowing for expression of Cro from pR. Cro is known to repress transcription of CI from pRM to prevent lysogeny. We show here that when Cro and CI are both present but at low levels, the low level of Cro initially stimulates the lytic promoters while CI repressor is still present, stimulating the level of Cro to a concentration required for pRM repression. Cro has no stimulatory effect without the presence of CI. We propose that this early auto-activating role of Cro at lower concentrations is essential in the developmental switch to lytic growth, whereas pRM repression by Cro at relatively higher concentrations avoids restoring lysogeny.
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