Evidence map›Paper›PMID 29157966›Full record

ArticleTrends in microbiology2018

Antibiotic Killing through Incomplete DNA Repair.

Benno H Ter Kuile, Marloes Hoeksema

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Synergistic Quinolone Sensitization by Targeting theAntimicrobial agents and chemotherapy · 2021
    Article
  3. Frontiers in microbiology · 2021
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Benno H Ter KuileLaboratory for Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands; Netherlands Food and Consumer Product Safety Authority, Office for Risk Assessment, Utrecht, The Netherlands. Electronic address: B.H.terKuile@uva.nl.
Marloes HoeksemaLaboratory for Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.
University of Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two recent studies show that incomplete repair of DNA damage due to oxidized nucleotides is crucial for reactive oxygen species (ROS)-related antimicrobial lethality. Using widely different experimental approaches they both reach the same conclusions on the role of downstream ROS production in cell killing upon exposure to bactericidal antimicrobials.

Indexed as

Anti-Bacterial AgentsDNA RepairDNA DamageOxidation-ReductionReactive Oxygen SpeciesAnti-Bacterial AgentsReactive Oxygen Speciesbactericidal antibioticsDNA mismatch repairMalE-LacZ hybrid proteinreactive oxygen speciestrimethoprim

Identifiers

PMID29157966
OpenAlexW2770163682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.