Evidence map›Paper›PMID 29157935›Full record

ArticleStem cell research2017

A quiet space during rush hour: Quiescence in primordial germ cells.

Nathalie Oulhen, Gary Wessel

Abstract read
In one paragraph

Article in Stem cell research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Somatic cell conversion to a germ cell lineage: A violation or a revelation?Journal of experimental zoology. Part B, Molecular and developmental evolution · 2021
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nathalie OulhenDepartment of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, RI 02912, United States.
Gary WesselDepartment of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, RI 02912, United States. Electronic address: rhet@brown.edu.

Funding

Mechanisms of quiescence in primordial germ cellsR01GM125071 · NIGMS · BROWN UNIVERSITY · PI WESSEL, GARY M · 2017 to 2020
$1.4M
NIGMS NIH HHS R01 GM125071
6 · The paper itself

Abstract

Quiescence is a common character in stem cells. Low cellular activity in these cells may function to minimize the potential damaging effects of oxidative stress, reduce the number of cells needed for tissue replenishment, and as a consequence, perhaps occupy unique niches. Quiescent stem cells are found in many adult human tissues, the hematopoietic stem cells are paradigmatic, and more recently it appears that stem cell of the germ line in many animals display quiescence characters. Here we explore the diversity of quiescence phenotypes in primordial germ cells, leveraging the diverse mechanisms of germ cell formation to extract evolutionary significance to common processes.

Indexed as

AnimalsCaenorhabditis elegansCell DifferentiationCell DivisionDrosophilaGerm CellsHematopoietic Stem CellsMice

Identifiers

PMID29157935
PMCPMC5732843

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.