ArticleMicrobiome2017
Characterization of the upper and lower respiratory tract microbiota in Piedmontese calves.
Article in Microbiome, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Effect of bovine respiratory disease on the respiratory microbiome: a meta-analysis.Frontiers in cellular and infection microbiology · 2023Pooled it
- Associations Between Fine Particulate Matter-Associated Bacteria and Respiratory Tract Microbiota in Pigs.Animals : an open access journal from MDPI · 2026Article
- Respiratory bacteriome and its predicted functional profiles in blue whales (Balaenoptera musculus).Scientific reports · 2025Article
- Decoding the dynamics of calves' respiratory and gut microbiota: exploring stability, resistance, and individual patterns.Animal microbiome · 2025Article
- A novel attenuated and markerVirulence · 2025Article
- A Comprehensive Review: Molecular Diagnostics and Multi-Omics Approaches to Understanding Bovine Respiratory Disease.Veterinary sciences · 2025Review
- A Study on the Changing Law of Bacterial Communities in the Milk of Bactrian Camels with Subclinical Mastitis.Microorganisms · 2025Article
- Nasal pathobiont abundance is a moderate feedlot-dependent indicator of bovine respiratory disease in beef cattle.Animal microbiome · 2025Article
- Comparative evaluation of lower respiratory tract microbiota in healthy and BRD-affected calves in Egypt.Tropical animal health and production · 2025Article
- Nasal pathobiont abundance does not differ between dairy cattle with or without clinical symptoms of bovine respiratory disease.Animal microbiome · 2025Article
- Characterization of blood microbial population in beef calves with clinical signs of sepsis using 16S rRNA gene sequencing.PloS one · 2025Article
- The forecasting power of the mucin-microbiome interplay in livestock respiratory diseases.The veterinary quarterly · 2024Article
- Gut-associated microbes are present and active in the pig nasal cavity.Scientific reports · 2024Article
- Investigation of the Optimal Immunization Dose and Protective Efficacy of an Attenuated and MarkerAnimals : an open access journal from MDPI · 2024Article
- Insights into microbial compositions of the respiratory tract of neonatal dairy calves in a longitudinal probiotic trial through 16S rRNA sequencing.Frontiers in microbiology · 2024Article
- Investigation of the safety and protective efficacy of an attenuated and markerFrontiers in immunology · 2024Article
- Article
- Effect of Capsaicin Addition on Antioxidant Capacity, Immune Performance and Upper Respiratory Microbiota in Nursing Calves.Microorganisms · 2023Article
- Meta-Analysis on the Global Prevalence of Tetracycline Resistance inVeterinary sciences · 2023Review
- The Fungal and Bacterial Interface in the Respiratory Mycobiome with a Focus onLife (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe microbiota of the bovine upper respiratory tract has been recently characterized, but no data for the lower respiratory tract are available. A major health problem in bovine medicine is infectious bronchopneumonia, the most common respiratory syndrome affecting cattle. With this study, we used 16S rRNA gene sequencing to characterize and compare the microbial community composition of the upper and lower respiratory tracts in calves.
resultsThe microbiota of the upper (nasal swab [NS]) and the lower (trans-tracheal aspiration [TTA]) respiratory tracts of 19 post-weaned Piedmontese calves with (8/19) and without (11/19) clinical signs of respiratory disease, coming from six different farms, was characterized by 16S rRNA gene metabarcoding. A total of 29 phyla (29 in NS, 21 in TTA) and 305 genera (289 in NS, 182 in TTA) were identified. Mycoplasma (60.8%) was the most abundant genus identified in both the NS (27.3%) and TTA (76.7%) samples, followed by Moraxella (16.6%) in the NS and Pasteurella (7.3%) in the TTA samples. Pasteurella multocida (7.3% of total operational taxonomic units [OTUs]) was the most abundant species in the TTA and Psychrobacter sanguinis (1.1% of total OTUs) in the NS samples. Statistically significant differences between the NS and the TTA samples were found for both alpha (Shannon index, observed species, Chao1 index, and Simpson index; P = 0.001) and beta (Adonis; P = 0.001) diversity. Comparison of the NS and TTA samples by farm origin and clinical signs revealed no statistical difference (P > 0.05), except for farm origin for the NS samples when compared by the unweighted UniFrac metric (P = 0.05).
conclusionsUsing 16S rRNA gene sequencing, we characterized the microbiota of the upper and lower respiratory tracts of calves, both healthy individuals and those with clinical signs of respiratory disease. Our results suggest that environmental factors may influence the composition of the upper airway microbiota in cattle. While the two microbial communities (upper and lower airways) differed in microbial composition, they shared several OTUs, suggesting that the lung microbiota may be a self-sustaining, more homogeneous ecosystem, influenced by the upper respiratory tract microbiota.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.