ArticleParasites & vectors2017
Genotyping of polymorphic effectors of Toxoplasma gondii isolates from China.
Article in Parasites & vectors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- High-resolution melting (HRM)-based genotyping of Toxoplasma gondii in meat products: comparative evaluation of ROP18, ROP5, and B1 gene markers.World journal of microbiology & biotechnology · 2026Article
- Genetic diversity of Toxoplasma gondii isolates from members of the families camelidae and equidae worldwide: a systematic review.Irish veterinary journal · 2026Review
- A novel anti-Microbiology spectrum · 2026Article
- Population genetic structure of zoonoticScience in One Health · 2026Article
- Investigation of Virulence-Related Markers in Atypical Strains ofMicroorganisms · 2025Article
- Toxoplasma-host endoplasmic reticulum interaction: HowCurrent research in microbial sciences · 2024Review
- Studies on the mechanism of Toxoplasma gondii Chinese 1 genotype Wh6 strain causing mice abnormal cognitive behavior.Parasites & vectors · 2023Article
- Toxoplasma gondii dense granule protein 3 promotes endoplasmic reticulum stress-induced apoptosis by activating the PERK pathway.Parasites & vectors · 2022Article
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- Evidence of red panda as an intermediate host ofInternational journal for parasitology. Parasites and wildlife · 2019Article
- Toxoplasma gondii dense granule protein 15 induces apoptosis in choriocarcinoma JEG-3 cells through endoplasmic reticulum stress.Parasites & vectors · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundToxoplasma gondii is an opportunistic protozoan apicomplexan and obligate intracellular parasite that infects a wide range of animals and humans. Rhoptry proteins 5 (ROP5), ROP16, ROP18 and dense granules 15 (GRA15) are the important effectors secreted by T. gondii which link to the strain virulence for mice and modulate the host's response to the parasite. Little has been known about these molecules as well as GRA3 in type Chinese 1 strains that show polymorphism among strains of archetypical genotypes. This study examined the genetic diversity of these effectors and its correlated virulence in mice among T. gondii isolates from China.
resultsTwenty-one isolates from stray cats were detected, of which 15 belong to Chinese 1, and 6 to ToxoDB #205. Wh6 isolate, a Chinese 1 strain, has an avirulent phenotype. PCR-RFLP results of ROP5 and ROP18 presented few variations among the strains. Genotyping of GRA15 and ROP16 revealed that all the strains belong to type II allele except Xz7 which carries type I allele. ROP16 amino acid alignment at 503 locus demonstrated that 17 isolates are featured as type I or type III (ROP16
conclusionsPCR-RFLP and sequence alignment analyses of ROP5, ROP16, ROP18, GRA3, and GRA15 in T. gondii revealed that strains with the same genotype may have variations in some of their key genes. GRA3 variation exhibited by Wh6 strain may be associated with the difference in phenotype and pathogenesis.
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