ArticleVirology journal2017
Coinfection with Haemophilus parasuis serovar 4 increases the virulence of porcine circovirus type 2 in piglets.
Article in Virology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- The Prevalence and Genetic Diversity of Porcine Circoviruses (PCVs) in Eastern China During 2010-2016 and 2023-2024.Veterinary sciences · 2026Article
- Global whole-genome, phylodynamic, and machine-learning analysis ofApplied and environmental microbiology · 2026Article
- Development and Application of Fluorescent and Lateral Flow Dipstick Recombinase-Aided Amplification for Rapid Detection ofVeterinary sciences · 2025Article
- Article
- Establishment and validation of a simple and accurate qPCR detection method for Haemophilus parasuis.Scientific reports · 2025Article
- Enhanced Systemic and Mucosal Immune Responses toVaccines · 2024Article
- Genomic insight into the diversity ofmSphere · 2024Article
- Article
- Temporal Patterns of Phenotypic Antimicrobial Resistance and Coinfecting Pathogens inPathogens (Basel, Switzerland) · 2022Article
- Investigation and analysis of etiology associated with porcine respiratory disease complex in China from 2017 to 2021.Frontiers in veterinary science · 2022Article
- Transcriptome profiling identifies immune response genes against porcine reproductive and respiratory syndrome virus andJournal of veterinary science · 2022Article
- Comparison of PK/PD Targets and Cutoff Values for Danofloxacin AgainstFrontiers in veterinary science · 2022Article
- The ultrasonically treated nanoliposomes containing PCV2 DNA vaccine expressing gC1qR binding site mutant Cap is efficient in mice.Frontiers in microbiology · 2022Article
- Application of mouse model for evaluation of recombinant LpxC and GmhA as novel antigenic vaccine candidates of Glaesserella parasuis serotype 13.The Journal of veterinary medical science · 2021Article
- Macrophage Polarization Modulated by Porcine Circovirus Type 2 Facilitates Bacterial Coinfection.Frontiers in immunology · 2021Article
- Development and Validation of a Loop-Mediated Isothermal Amplification (LAMP) Assay for Rapid Detection ofMicroorganisms · 2020Article
- Pigs Overexpressing Porcine β-Defensin 2 Display Increased Resilience toAntibiotics (Basel, Switzerland) · 2020Article
- Epidemiological and PK/PD cutoff values determination and PK/PD-based dose assessment of gamithromycin against Haemophilus parasuis in piglets.BMC veterinary research · 2020Article
- Porcine circovirus type 2 exploits JNK-mediated disruption of tight junctions to facilitate Streptococcus suis translocation across the tracheal epithelium.Veterinary research · 2020Article
- Porcine Circovirus Type 2 Suppresses IL-12p40 Induction via Capsid/gC1qR-Mediated MicroRNAs and Signalings.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostweaning multisystemic wasting syndrome (PMWS) is an emerging disease in swine. Pigs with PMWS are often infected with a variety of other pathogens, including bacteria, viruses and mycoplasm, in addition to porcine circovirus type 2 (PCV2). PCV2 and Haemophilus parasuis serovar 4 (HPS4) coinfection remain epidemic in China.
methodsHere we report construction of a three-week-old naturally farrowed, colostrum-deprived (NFCD) piglet's infection model and demonstrate that PCV2-infected piglets with the HPS4 coinfection increased the virulence of PCV2 and these pathogens interact acquired PMWS.
resultsAll the single infected piglets were transiently bacteremic or viremic. All the PCV2/HPS4 coinfected piglets developed PMWS, characterized by dyspnea, anorexia, prostration and lose weight severely. Co-infection with PCV2 and HPS4 resulted in an increased amount of virus in serum and tissues, presented a slower generation and lower levels of antibodies against PCV2. Co-infection with PCV2 and HPS4 resulted in further reductions in total and differential peripheral blood leukocyte counts. Meantime, PCV2/ HPS4 coinfection potentiated the severity of lung and lymphoid lesions by PCV2-associated, increased the virulence of PCV2-antigen and enhanced the incidence of PMWS in piglets.
conclusionCo-infection with PCV2 and HPS4 induce the exacerbation of system injuries and enhance the pathogenicity of PCV2 in piglets.
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