ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2017
The impact of signal-to-noise ratio, diffusion-weighted directions and image resolution in cardiac diffusion tensor imaging - insights from the ex-vivo rat heart.
Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The Effect of Voxel Volume and Voxel Shape on Cardiac Diffusion Tensor Imaging Metrics.Magnetic resonance in medicine · 2026Article
- Comparison of cardiac diffusion MRI using multiple prospective respiratory motion correction techniques.Magnetic resonance in medicine · 2026Article
- Cardiac diffusion kurtosis imaging in the human heart in vivo using 300 mT/m gradients.Magnetic resonance in medicine · 2025Article
- In vivo diffusion MRI of the human heart using a 300 mT/m gradient system.Magnetic resonance in medicine · 2024Article
- The comparison of diffusion tensor imaging in human hearts between 1.5 T and 3.0 T.BMC medical imaging · 2023Article
- Detection of Intramyocardial Iron in Patients Following ST-Elevation Myocardial Infarction Using Cardiac Diffusion Tensor Imaging.Journal of magnetic resonance imaging : JMRI · 2022Article
- Validation of cardiac diffusion tensor imaging sequences: A multicentre test-retest phantom study.NMR in biomedicine · 2022Article
- Article
- 3D MRI of explanted sheep hearts with submillimeter isotropic spatial resolution: comparison between diffusion tensor and structure tensor imaging.Magma (New York, N.Y.) · 2021Article
- In vivo tensor-valued diffusion MRI of focal demyelination in white and deep grey matter of rodents.NeuroImage. Clinical · 2021Article
- Article
- Journal of Cardiovascular Magnetic Resonance: 2017/2018 in review.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2019Review
- Spin echo based cardiac diffusion imaging at 7T: An ex vivo study of the porcine heart at 7T and 3T.PloS one · 2019Article
- Journal of Cardiovascular Magnetic Resonance 2017.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundCardiac diffusion tensor imaging (DTI) is limited by scan time and signal-to-noise (SNR) restrictions. This invariably leads to a trade-off between the number of averages, diffusion-weighted directions (ND), and image resolution. Systematic evaluation of these parameters is therefore important for adoption of cardiac DTI in clinical routine where time is a key constraint.
methodsHigh quality reference DTI data were acquired in five ex-vivo rat hearts. We then retrospectively set 2 ≤ SNR ≤ 97, 7 ≤ ND ≤ 61, varied the voxel volume by up to 192-fold and investigated the impact on the accuracy and precision of commonly derived parameters.
resultsFor maximal scan efficiency, the accuracy and precision of the mean diffusivity is optimised when SNR is maximised at the expense of ND. With typical parameter settings used clinically, we estimate that fractional anisotropy may be overestimated by up to 13% with an uncertainty of ±30%, while the precision of the sheetlet angles may be as poor as ±31°. Although the helix angle has better precision of ±14°, the transmural range of helix angles may be under-estimated by up to 30° in apical and basal slices, due to partial volume and tapering myocardial geometry.
conclusionsThese findings inform a baseline of understanding upon which further issues inherent to in-vivo cardiac DTI, such as motion, strain and perfusion, can be considered. Furthermore, the reported bias and reproducibility provides a context in which to assess cardiac DTI biomarkers.
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