ArticleBMC medicine2017
Telomere tracking from birth to adulthood and residential traffic exposure.
Article in BMC medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Extracurricular physical activity and telomere length in childhood: findings from the INMA study.Pediatric research · 2026Article
- Machine learning prediction of osteoarthritis risk from volatile organic compound exposure using SHAP interpretation in US adults.Scientific reports · 2025Article
- Assortative breeding experiment in a songbird suggests telomere length is determined during early life rather than at conception.Scientific reports · 2025Article
- The multi-omics signatures of telomere length in childhood.BMC genomics · 2025Article
- Sedentary Behaviour and Telomere Length Shortening during Early Childhood: Evidence from the Multicentre Prospective INMA Cohort Study.International journal of environmental research and public health · 2023Article
- Early-life residential green spaces and traffic exposure in association with young adult body composition: a longitudinal birth cohort study of twins.Environmental health : a global access science source · 2023Article
- Interrelationships and determinants of aging biomarkers in cord blood.Journal of translational medicine · 2022Article
- Shorter periconception maternal telomere length and the risk of congenital cardiac outflow defects in the offspring.European journal of clinical investigation · 2022Article
- Genetic regulation of newborn telomere length is mediated and modified by DNA methylation.Frontiers in genetics · 2022Article
- Genetic, Environmental and Lifestyle Determinants of Accelerated Telomere Attrition as Contributors to Risk and Severity of Multiple Sclerosis.Biomolecules · 2021Review
- Pleiotropic effects of telomere length loci with brain morphology and brain tissue expression.Human molecular genetics · 2021Article
- Serum gamma-glutamyl transferase, a marker of alcohol intake, is associated with telomere length and cardiometabolic risk in young adulthood.Scientific reports · 2021Article
- Different epigenetic signatures of newborn telomere length and telomere attrition rate in early life.Aging · 2021Article
- Short Leukocyte Telomeres, But Not Telomere Attrition Rates, Predict Memory Decline in the 20-Year Longitudinal Betula Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Longitudinal telomere length and body composition in healthy term-born infants during the first two years of life.PloS one · 2021Article
- Placental and Cord Blood Telomere Length in Relation to Maternal Nutritional Status.The Journal of nutrition · 2020Article
- Telomere length: how the length makes a difference.Molecular biology reports · 2020Review
- Preconception telomere length as a novel maternal biomarker to assess the risk of spina bifida in the offspring.Birth defects research · 2020Article
- Association of Parental Socioeconomic Status and Newborn Telomere Length.JAMA network open · 2020Article
- Antiaging effect of a Jianpi-yangwei formula in Caenorhabditis elegans.BMC complementary and alternative medicine · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundTelomere attrition is extremely rapid during the first years of life, while lifestyle during adulthood exerts a minor impact. This suggests that early life is an important period in the determination of telomere length. We investigated the importance of the early-life environment on both telomere tracking and adult telomere length.
methodsAmong 184 twins of the East Flanders Prospective Twin Survey, telomere length in placental tissue and in buccal cells in young adulthood was measured. Residential addresses at birth and in young adulthood were geocoded and residential traffic and greenness exposure was determined.
resultsWe investigated individual telomere tracking from birth over a 20 year period (mean age (SD), 22.6 (3.1) years) in association with residential exposure to traffic and greenness. Telomere length in placental tissue and in buccal cells in young adulthood correlated positively (r = 0.31, P < 0.0001). Persons with higher placental telomere length at birth were more likely to have a stronger downward shift in telomere ranking over life (P < 0.0001). Maternal residential traffic exposure correlated inversely with telomere length at birth. Independent of birth placental telomere length, telomere ranking between birth and young adulthood was negatively and significantly associated with residential traffic exposure at the birth address, while traffic exposure at the residential address at adult age was not associated with telomere length.
conclusionsLongitudinal evidence of telomere length tracking from birth to adulthood shows inverse associations of residential traffic exposure in association with telomere length at birth as well as accelerated telomere shortening in the first two decades of life.
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