ArticleBMC infectious diseases2017
Remarkable spatial variation in the seroprevalence of Coxiella burnetii after a large Q fever epidemic.
Article in BMC infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 13 citations in OpenAlex.
- Cross-Sectional Study of Q Fever Seroprevalence among Blood Donors, Israel, 2021.Emerging infectious diseases · 2024Article
- Literature review on micro-organisms from domestic goats potentially causing human pneumonia.Infection ecology & epidemiology · 2024Review
- Transmission dynamics of Q fever in French Guiana: A population-based cross-sectional study.Lancet regional health. Americas · 2022Article
- Targeted Screening for Chronic Q Fever, the Netherlands.Emerging infectious diseases · 2022Article
- Seroprevalence and risk factors of antibodies againstEpidemiology and infection · 2021Article
- Cost-effectiveness of Screening Program for Chronic Q Fever, the Netherlands.Emerging infectious diseases · 2020Article
- Seroprevalence ofOpen forum infectious diseases · 2019Article
- Attitude toward livestock farming does not influence the earlier observed association between proximity to goat farms and self-reported pneumonia.Environmental epidemiology (Philadelphia, Pa.) · 2019Article
- Notification data and criteria during a large Q-fever epidemic reassessed.Epidemiology and infection · 2019Article
- Chronic Q Fever with Vascular Involvement: Progressive Abdominal Pain in a Patient with Aortic Aneurysm Repair in the United States.Case reports in infectious diseases · 2019Article
- Zoonoses under our noses.Microbes and infectionReview
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrior to the 2007-2010 Q fever epidemic in the Netherlands, the seroprevalence of antibodies against Coxiella burnetii in the general population was 1.5%, which is low compared to other countries. We aimed to determine the seroprevalence after the Q fever epidemic among people living in the affected area, compare the seroprevalence with the incidence of Q fever notifications during the 2007-2010 Q fever epidemic, and to identify farm exposures associated with having antibodies against C. burnetii.
methodsDuring the period March 2014-February 2015, residents aged 18-70 years from two provinces were invited by general practitioners to complete a questionnaire on their symptoms and personal characteristics and to submit a blood sample. We used the mandatory provincial database of livestock licences to calculate distance to farms/farm animals for each participant. To compare ELISA-positive participants for C. burnetii antibodies with those who were negative, we calculated prevalence ratios (PR) using binominal regression. We compared the C. burnetii seroprevalence in the period March 2014-February 2015 with the incidence of Q fever notifications during the 2007-2010 Q fever epidemic at municipal level by calculating the Spearman correlation coefficient.
resultsOf the 2296 participants (response rate: 34%), 6.1% (n = 139, 95% CI 5.1-7.1%) had C. burnetii antibodies (range in municipalities: 1.7-14.1%). C. burnetii seroprevalence was higher in individuals living within 1000 m of goat farms (PR 3.0; 95% CI 1.4-6.4) or within 1000 m of > 50 goats (PR 1.9; 95% CI 1.2-3.0). Seroprevalence increased with decreasing distance to the closest goat farm that was infected during the epidemic years (< 500 m, PR 9.5, 95% CI 2.8-32; 500-1000 m, PR 4.5, 95% CI 2.6-7.7; 1000-1500 m, PR 2.2, 95% CI 1.1-4.3, 1500-2000 m, PR 1.2, 95% CI 0.6-2.5; > 2000 reference group). There was no significant correlation between C. burnetii seroprevalence and Q fever incidence during the 2007-2010 epidemic (r
conclusionsResults showed a remarkable spatial variation in C. burnetii seroprevalence in a relatively small livestock dense area. It confirms previous evidence that the Q fever epidemic was primarily the result of airborne C. burnetii transmission from Q fever affected goat farms.
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