ArticleBMC pulmonary medicine2017
Combined effects of leaks, respiratory system properties and upper airway patency on the performance of home ventilators: a bench study.
Article in BMC pulmonary medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- Residual Apnoea-Hypopnoea Index Measurement from Positive Airway Pressure Devices versus Home Polygraphy: A Method Comparison Study Using Real-World Data.Respiration; international review of thoracic diseases · 2026Article
- Bench evaluation of six non-invasive ventilation home ventilators: comparison with an ICU ventilator and unsupervised clustering.BMJ open respiratory research · 2025Article
- The Use of Bi-Nasal Prongs for Delivery of Non-Invasive Ventilation to Foals.Animals : an open access journal from MDPI · 2024Article
- Are all ventilators for NIV performing the same? A bench analysis.Journal of clinical monitoring and computing · 2023Article
- Practical Guide to Management of Long-Term Noninvasive Ventilation for Adults With Chronic Neuromuscular Disease.Respiratory care · 2023Review
- Ventilators, Settings, Autotitration Algorithms.Journal of clinical medicine · 2023Review
- Monitoring Systems in Home Ventilation.Journal of clinical medicine · 2023Review
- Responses of Bilevel Ventilators to Unintentional Leak: A Bench Study.Healthcare (Basel, Switzerland) · 2022Article
- Factors affecting abnormal triggering with non-invasive ventilators: A before-and-after study.The clinical respiratory journal · 2022Article
- Addition of bacterial filter alters positive airway pressure and non-invasive ventilation performances.The European respiratory journal · 2022Article
- Precision medicine is coming to town: personalising home ventilatory equipment in COPD patients with chronic hypercapnic respiratory failure.European respiratory review : an official journal of the European Respiratory Society · 2019Review
- Use of prototype bi-nasal prongs for noninvasive ventilation in foals.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCombined effects of leaks, mechanical property of respiratory system and upper airway (UA) patency on patient-ventilator synchrony (PVA) and the level of clinically "tolerable" leaks are not well established in home ventilators.
methodsWe comparatively assessed on a bench model, the highest leak level tolerated without inducing significant asynchrony ("critical leak") in three home ventilators (Astral 150, Trilogy 100 and Vivo 60; noted as A150, T100 and V60 respectively) subjected to three simulated diseased respiratory conditions: chronic obstructive pulmonary disease (COPD), obesity hypoventilation (OHS) and neuromuscular disorders (NMD), with both open and closed UA. Also, total leak values in the device reports were compared to the bench-measured values.
resultsWith open UA, all ventilators were able to avoid asynchrony up to a 30 L/min leak and even to 55 L/min in some cases. UA closure and respiratory diseases especially OHS influenced PVA. With closed UA, the critical leak of A150 and T100 remained higher than 55 L/min in COPD and OHS, while for V60 decreased to 41 and 33 L/min respectively. In NMD with closed UA, only T100 reached a high critical leak of 69 L/min. Besides, inspiratory trigger sensitivity change was often necessary to avoid PVA.
conclusionsHome ventilators were able to avoid PVA in high-level leak conditions. However, asynchrony appeared in cases of abnormal mechanical properties of respiratory system or closed UA. In case of closed UA, the EPAP should be adjusted prior to the inspiratory trigger.
trial registrationNot applicable.
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