Evidence map›Paper›PMID 29157162›Full record

ArticleJournal of biological dynamics2018

Discrete stochastic analogs of Erlang epidemic models.

Wayne M Getz, Eric R Dougherty

Abstract read
In one paragraph

Article in Journal of biological dynamics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  5. Article
  6. Article
  7. Article
  8. Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021
    Review
  9. Dynamics of SARS-CoV-2 with waning immunity in the UK population.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Adequacy of SEIR models when epidemics have spatial structure: Ebola in Sierra Leone.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Wayne M Getza Department of Environmental Science, Policy, and Management , University of California, Berkeley , Berkeley , CA , USA.
Eric R Doughertya Department of Environmental Science, Policy, and Management , University of California, Berkeley , Berkeley , CA , USA.

Funding

The ecology of environmentally maintained episodic anthrax in Esotha, NamibiaR01GM083863 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI GETZ, WAYNE M · 2008 to 2011
$1.7M
Spatio-temporally explicit estimation of R0 for pathogens with environmentally-mediated transmissionR01GM117617 · NIGMS · UNIVERSITY OF FLORIDA · PI BLACKBURN, JASON K · 2015 to 2018
$1.5M
NIGMS NIH HHS R01 GM083863NIGMS NIH HHS R01 GM117617
6 · The paper itself

Abstract

Erlang differential equation models of epidemic processes provide more realistic disease-class transition dynamics from susceptible (S) to exposed (E) to infectious (I) and removed (R) categories than the ubiquitous SEIR model. The latter is itself is at one end of the spectrum of Erlang SE[Formula: see text]I[Formula: see text]R models with [Formula: see text] concatenated E compartments and [Formula: see text] concatenated I compartments. Discrete-time models, however, are computationally much simpler to simulate and fit to epidemic outbreak data than continuous-time differential equations, and are also much more readily extended to include demographic and other types of stochasticity. Here we formulate discrete-time deterministic analogs of the Erlang models, and their stochastic extension, based on a time-to-go distributional principle. Depending on which distributions are used (e.g. discretized Erlang, Gamma, Beta, or Uniform distributions), we demonstrate that our formulation represents both a discretization of Erlang epidemic models and generalizations thereof. We consider the challenges of fitting SE[Formula: see text]I[Formula: see text]R models and our discrete-time analog to data (the recent outbreak of Ebola in Liberia). We demonstrate that the latter performs much better than the former; although confining fits to strict SEIR formulations reduces the numerical challenges, but sacrifices best-fit likelihood scores by at least 7%.

Indexed as

EpidemicsModels, BiologicalComputer SimulationHemorrhagic Fever, EbolaHumansIncidenceMonte Carlo MethodPrevalenceProbabilityStochastic Processes92D30Boxcar modelsdiscrete-time modelsDistributed-delayEbolagamma distributed waiting times

Identifiers

PMID29157162
PMCPMC6120589

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.