ArticleAutophagy2018
Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6
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Article in Autophagy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
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Who cites it
27 citing papers in PubMed, 38 citations in OpenAlex.
- C-terminal extension of HSPB6 in a family with myopathy and cataract.Human molecular genetics · 2026Article
- Cardiomyocyte programmed cell death in dilated cardiomyopathy: molecular crosstalk and therapeutic implications.Frontiers in cell and developmental biology · 2026Review
- Transcriptomic and flavor metabolomic exploration of the genetic basis of meat quality and flavor in Tibetan sheep.BMC genomics · 2025Article
- The elucidation of the dual role of Beclin-1 in ischemic stroke through systems biology modeling.iScience · 2025Article
- Mechanism of small heat shock protein client sequestration and induced polydispersity.Nature communications · 2025Article
- Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues.ESC heart failure · 2025Review
- Small HSPs at the crossroad between protein aggregation, autophagy and unconventional secretion: clinical implications and potential therapeutic opportunities in the context of neurodegenerative diseases.Frontiers in cell and developmental biology · 2025Review
- RNA sequencing and proteomic profiling reveal alterations by MPTP in chronic stomach mucosal injury in tree shrew Chinese (Tupaia belangeri chinensis).Scientific reports · 2024Article
- The role of heat shock proteins in the pathogenesis of heart failure (Review).International journal of molecular medicine · 2023Review
- Autophagy in Heart Failure: Insights into Mechanisms and Therapeutic Implications.Journal of cardiovascular development and disease · 2023Review
- Review
- A novel peptide HSP-17 ameliorates oxidative stress injury and apoptosis in H9c2 cardiomyocytes by activating the PI3K/Akt pathway.Annals of translational medicine · 2022Article
- The Role of Small Heat Shock Proteins in Protein Misfolding Associated Motoneuron Diseases.International journal of molecular sciences · 2022Review
- Animal Models of Cardiovascular Complications of Pregnancy.Circulation research · 2022Review
- Insights on Human Small Heat Shock Proteins and Their Alterations in Diseases.Frontiers in molecular biosciences · 2022Review
- Genetics of Peripartum Cardiomyopathy: Current Knowledge, Future Directions and Clinical Implications.Genes · 2021Review
- The Cardioprotective PKA-Mediated Hsp20 Phosphorylation Modulates Protein Associations Regulating Cytoskeletal Dynamics.International journal of molecular sciences · 2020Article
- Tissue-specific small heat shock protein 20 activation is not associated with traditional autophagy markers in Ossabaw swine with cardiometabolic heart failure.American journal of physiology. Heart and circulatory physiology · 2020Article
- Development of a novel prognostic signature for predicting the overall survival of bladder cancer patients.Bioscience reports · 2020Article
- Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage.Redox biology · 2020Article
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 2 countries.
Guan-Sheng Liua Department of Pharmacology & System Physiology , University of Cincinnati College of Medicine, Cincinnati , OH , USA.ORCID 0000-0003-0016-8607
Hongyan Zhua Department of Pharmacology & System Physiology , University of Cincinnati College of Medicine, Cincinnati , OH , USA.ORCID 0000-0002-5985-8533
Wen-Feng Caib Department of Pathology & Lab Medicine , University of Cincinnati College of Medicine, Cincinnati , OH , USA.ORCID 0000-0002-1499-4347
Xiaohong Wanga Department of Pharmacology & System Physiology , University of Cincinnati College of Medicine, Cincinnati , OH , USA.ORCID 0000-0001-9659-5739
Min Jiangc Department of Internal Medicine , University of Cincinnati College of Medicine. Cincinnati , OH , USA.ORCID 0000-0003-2507-368X
Kobina Essandoha Department of Pharmacology & System Physiology , University of Cincinnati College of Medicine, Cincinnati , OH , USA.ORCID 0000-0002-8088-4082
Elizabeth Vafiadakid Molecular Biology Division, Center for Basic Research, Biomedical Research Foundation of the Academy of Athens , Athens , Greece.ORCID 0000-0001-9931-7099
Kobra Haghighia Department of Pharmacology & System Physiology , University of Cincinnati College of Medicine, Cincinnati , OH , USA.ORCID 0000-0002-3122-3894
Chi Keung Lama Department of Pharmacology & System Physiology , University of Cincinnati College of Medicine, Cincinnati , OH , USA.ORCID 0000-0003-4565-9426
George Gardnera Department of Pharmacology & System Physiology , University of Cincinnati College of Medicine, Cincinnati , OH , USA.ORCID 0000-0001-6927-5561
George Adlya Department of Pharmacology & System Physiology , University of Cincinnati College of Medicine, Cincinnati , OH , USA.ORCID 0000-0002-5204-5847
Persoulla Nicolaoua Department of Pharmacology & System Physiology , University of Cincinnati College of Medicine, Cincinnati , OH , USA.ORCID 0000-0001-7532-4833
Despina Sanoudoud Molecular Biology Division, Center for Basic Research, Biomedical Research Foundation of the Academy of Athens , Athens , Greece.ORCID 0000-0003-3704-1941
Qiangrong Liange Department of Biomedical Sciences , New York Institute of Technology College of Osteopathic Medicine , Old Westbury , NY , USA.ORCID 0000-0002-6123-5685
Jack Rubinsteinc Department of Internal Medicine , University of Cincinnati College of Medicine. Cincinnati , OH , USA.ORCID 0000-0002-8811-1551
Guo-Chang Fana Department of Pharmacology & System Physiology , University of Cincinnati College of Medicine, Cincinnati , OH , USA.ORCID 0000-0002-0439-8277
Evangelia G Kraniasa Department of Pharmacology & System Physiology , University of Cincinnati College of Medicine, Cincinnati , OH , USA.ORCID 0000-0002-4621-6179
University of Cincinnati Medical Center · USBiomedical Research Foundation of the Academy of Athens · GRNew York Institute of Technology · US
Funding
Cardiac Sarcoplasmic Reticulum Calcium Cycling ProteinsR01HL064018 · NHLBI · UNIVERSITY OF CINCINNATI · PI KRANIAS, EVANGELIA G · 2000 to 2017
$6.8MTARGETED ABLATION AND ALTERATION OF MOUSE PHOSPHOLAMBANR01HL026057 · NHLBI · UNIVERSITY OF CINCINNATI · PI KRANIAS, EVANGELIA G · 1985 to 2017
$5.3MRoles of Hsp20-Exosomes in Myocardial AngiogenesisR01HL087861 · NHLBI · UNIVERSITY OF CINCINNATI · PI FAN, GUO-CHANG · 2007 to 2017
$4.2MDuplex miR-223 and Exosomes in SepsisR01GM112930 · NIGMS · UNIVERSITY OF CINCINNATI · PI FAN, GUO-CHANG · 2015 to 2018
$1.2MTARGETED ABLATION AND ALTERATION OF PHOSPHOLAMBANR37HL026057 · NHLBI · UNIVERSITY OF CINCINNATI · PI KRANIAS, EVANGELIA G · 1994 to 2003
$1.1MNHLBI NIH HHS R01 HL026057NHLBI NIH HHS R01 HL064018NHLBI NIH HHS R01 HL087861NHLBI NIH HHS R37 HL026057NIGMS NIH HHS R01 GM112930
Abstract
HSPB6/Hsp20 (heat shock protein family B [small] member 6) has emerged as a novel cardioprotector against stress-induced injury. We identified a human mutant of HSPB6 (HSPB6
Indexed as
AutophagyCardiomyopathy, DilatedAnimalsApoptosisBeclin-1Heart FailureHSP20 Heat-Shock ProteinsHumansMiceMice, TransgenicMutationMyocytes, CardiacProto-Oncogene Proteins c-bcl-2RatsRats, Sprague-DawleyUbiquitinationBeclin-1BECN1 protein, humanHSP20 Heat-Shock ProteinsHSPB6 protein, humanProto-Oncogene Proteins c-bcl-2autophagyBECN1heart failureHSPB6human mutation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.