ArticleThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians2019
Early prenatal vitamin D concentrations and social-emotional development in infants.
Article in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Maternal Vitamin D Levels during Pregnancy and Offspring Psychiatric Outcomes: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Neurodevelopmental effects of prenatal vitamin D in humans: systematic review and meta-analysis.Molecular psychiatry · 2020Pooled it
- Effects of vitamin D deficiency on neurobehavioural outcomes in children: a systematic review.Wellcome open research · 2020Pooled it
- Vitamin D and Child Neurodevelopment-A Post Hoc Analysis.Nutrients · 2023Trial
- Does gestational vitamin D attenuate the negative effects of prenatal depression on offspring emotional and behavioral problems? Findings in the ECHO cohort.Psychological medicine · 2026Article
- Prenatal vitamin D status and long-term neurocognitive outcomes: building on an emerging evidence base.Pediatric research · 2026Article
- The Neuroprotective Potential of Vitamin DNutrients · 2025Review
- Gestational vitamin D concentration and child cognitive development: a longitudinal cohort study in the Environmental influences on Child Health Outcomes Program.The American journal of clinical nutrition · 2025Article
- Diminished social motivation in early psychosis is associated with polygenic liability for low vitamin D.Translational psychiatry · 2024Article
- Vitamin D levels of pregnant immigrant women and developmental disorders of language, learning and coordination in offspring.PloS one · 2024Article
- "You are my sunshine, my only sunshine": maternal vitamin D status and supplementation in pregnancy and their effect on neonatal and childhood outcomes.Hormones (Athens, Greece) · 2023Review
- Maternal and neonatal blood vitamin D status and neurodevelopment at 24 months of age: a prospective birth cohort study.World journal of pediatrics : WJP · 2023Article
- Greater Gestational Vitamin D Status is Associated with Reduced Childhood Behavioral Problems in the Environmental Influences on Child Health Outcomes Program.The Journal of nutrition · 2023Article
- Prenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy.European child & adolescent psychiatry · 2023Article
- Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study.Molecular autism · 2022Article
- Maternal tobacco smoke exposure is associated with increased DNA methylation at human metastable epialleles in infant cord blood.Environmental epigenetics · 2022Article
- Prenatal vitamin D levels and child wheeze and asthma.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2021Article
- Maternal Plasma 25-Hydroxyvitamin D during Gestation Is Positively Associated with Neurocognitive Development in Offspring at Age 4-6 Years.The Journal of nutrition · 2021Article
- Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study.Nutrients · 2020Article
- Neonatal vitamin D levels and cognitive ability in young adulthood.European journal of nutrition · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundMany pregnant women in the United States have suboptimal vitamin D, but the impact on infant development is unclear. Moreover, no pregnancy-specific vitamin D recommendations have been widely accepted.
aimsGiven the ubiquitous expression of vitamin D receptors in the brain, we investigated the association between early prenatal plasma 25-hydroxyvitamin D (25(OH)D) concentrations and children's social and emotional development in the Newborn Epigenetic Study, a prospective study of pregnancies from 2009 to 2011 in Durham, North Carolina.
methodsWe measured 25(OH)D concentrations in first or second trimester plasma samples and categorized 25(OH)D concentrations into quartiles. Covariates were derived from maternal questionnaires. Mothers completed the Infant Toddler Social-Emotional Development Assessment when children were 12-24 months of age. We used multivariable linear regression to evaluate associations between 25(OH)D and specific behavior scores, adjusted for season of blood draw, maternal age, education, parity, smoking, marital status, prepregnancy BMI, and infant gender. We investigated effect-measure modification by race/ethnicity.
resultsOf the 218 mother-infant pairs with complete data, Black mothers had much lower 25(OH)D concentrations as compared to White and Hispanic mothers. After adjustment, lower prenatal 25(OH)D was associated with slightly higher (less favorable) Internalizing scores among White children, but lower (more favorable) Internalizing scores among Black and Hispanic children. Lower prenatal 25(OH)D also appears to be associated with higher (less favorable) dysregulation scores, though only among White and Hispanic children.
conclusionsThough imprecise, preliminary results warrant further investigation regarding a role for prenatal vitamin D on children's early social and emotional development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.