Evidence map›Paper›PMID 29156792›Full record

ArticleOncotarget2017

Liquid biopsy in colon cancer: comparison of different circulating DNA extraction systems following absolute quantification of

Vera Kloten, Nadine Rüchel, Nadina Ortiz Brüchle, Janina Gasthaus, Nils Freudenmacher, Florian Steib, Jolein Mijnes, Julian Eschenbruch, Marcel Binnebösel, Ruth Knüchel and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 4 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Circulating Cell-Free DNA and Colorectal Cancer: A Systematic Review.International journal of molecular sciences · 2018
    Pooled it
  5. Trial
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Investigation of plasma cell-free DNA as a potential biomarker in horses.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Vera KlotenMolecular Oncology Group, Institute of Pathology, University Hospital Aachen, Aachen, Germany.
Nadine RüchelMolecular Oncology Group, Institute of Pathology, University Hospital Aachen, Aachen, Germany.
Nadina Ortiz BrüchleMolecular Oncology Group, Institute of Pathology, University Hospital Aachen, Aachen, Germany.
Janina GasthausMolecular Oncology Group, Institute of Pathology, University Hospital Aachen, Aachen, Germany.
Nils FreudenmacherMolecular Oncology Group, Institute of Pathology, University Hospital Aachen, Aachen, Germany.
Florian SteibMolecular Oncology Group, Institute of Pathology, University Hospital Aachen, Aachen, Germany.
Jolein MijnesMolecular Oncology Group, Institute of Pathology, University Hospital Aachen, Aachen, Germany.
Julian EschenbruchMolecular Oncology Group, Institute of Pathology, University Hospital Aachen, Aachen, Germany.
Marcel BinneböselDepartment of Visceral and Transplantation Surgery, University Hospital Aachen, Aachen, Germany.
Ruth KnüchelMolecular Oncology Group, Institute of Pathology, University Hospital Aachen, Aachen, Germany.
Edgar DahlMolecular Oncology Group, Institute of Pathology, University Hospital Aachen, Aachen, Germany.
Universitätsklinikum Aachen · DERWTH Aachen University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-invasive molecular analysis of circulating tumor DNA (ctDNA) is a promising application in personalized cancer management, although there is still much to learn about the biological characteristics of ctDNA. The present study compared absolute amounts of

Indexed as

cfDNA extraction systemsctDNA quantificationintplex-allele specific PCRKRASliquid biopsy

Identifiers

PMID29156792
PMCPMC5689682
OpenAlexW2757002532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.