Evidence map›Paper›PMID 29156728›Full record

ArticleOncotarget2017

Long non-coding RNA HOTAIR acts as a competing endogenous RNA to promote malignant melanoma progression by sponging miR-152-3p.

Wenkang Luan, Rubo Li, Liang Liu, Xin Ni, Yan Shi, Yun Xia, Jinlong Wang, Feng Lu, Bin Xu

RetractedOpen access · diamondAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Pooled it
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  20. Epigenetic Changes and Functions in Pneumoconiosis.Oxidative medicine and cellular longevity · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Wenkang LuanDepartment of Plastic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Rubo LiDepartment of Neurosurgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Liang LiuDepartment of Neurosurgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Xin NiDepartment of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Yan ShiDepartment of Neurosurgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Yun XiaDepartment of Plastic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Jinlong WangDepartment of Plastic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Feng LuDepartment of Plastic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Bin XuDepartment of Plastic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Affiliated Hospital of Jiangsu University · CNJiangsu University · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HOX transcript antisense RNA (HOTAIR) is associated with the growth and metastasis of many human tumors, but its biological roles in malignant melanoma remain unclear. In this study, we show that HOTAIR is overexpressed in melanoma tissues and cells, especially in metastatic melanoma. High HOTAIR levels correlate with poor prognosis in melanoma patients. We also determined that HOTAIR functions as a competing endogenous RNA (ceRNA) for miR-152-3p. miR-152-3p was decreased and acted as a tumor suppressor in melanoma, and c-MET was the functional target of miR-152-3p. Furthermore, HOTAIR promotes the growth and metastasis of melanoma cells by competitively binding miR-152-3p, which functionally liberates c-MET mRNA and results in the activation of the downstream PI3k/Akt/mTOR signaling pathway. We determined that HOTAIR acts as a ceRNA to promote malignant melanoma progression by sponging miR-152-3p. This finding elucidates a new mechanism for HOTAIR in melanoma development and provides a potential therapeutic target for melanoma patients.

Indexed as

ceRNAc-METHOTAIRmalignant melanomamiR-152-3p

Identifiers

PMID29156728
PMCPMC5689618
OpenAlexW2744066849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.