ArticleOncotarget2017
Novel strategies of Raman imaging for brain tumor research.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 67 citations in OpenAlex.
- Alternative Methodology for Cortisol Evaluation Before and After Sheep Shearing Using Raman Spectroscopy: A Feasibility Study.Animals : an open access journal from MDPI · 2025Article
- Label-free optical imaging for brain cancer assessment.Trends in cancer · 2024Review
- Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic.Science advances · 2023Article
- Molecular Fingerprint Detection Using Raman and Infrared Spectroscopy Technologies for Cancer Detection: A Progress Review.Biosensors · 2023Review
- Combined Use of Frameless Neuronavigation and In Situ Optical Guidance in Brain Tumor Needle Biopsies.Brain sciences · 2023Article
- A Handheld Visible Resonance Raman Analyzer Used in Intraoperative Detection of Human Glioma.Cancers · 2023Article
- Biomineralogical signatures of breast microcalcifications.Science advances · 2023Article
- Identification of Therapeutic Targets for Medulloblastoma by Tissue-Specific Genome-Scale Metabolic Model.Molecules (Basel, Switzerland) · 2023Article
- Oil content analysis of corn seeds using a hand-held Raman spectrometer and spectral peak decomposition algorithm.Frontiers in plant science · 2023Article
- Lipid Alterations in Glioma: A Systematic Review.Metabolites · 2022Review
- Impact of preprocessing methods on the Raman spectra of brain tissue.Biomedical optics express · 2022Article
- Safe surgery for glioblastoma: Recent advances and modern challenges.Neuro-oncology practice · 2022Review
- Label-free discrimination of tumorigenesis stages using in vitro prostate cancer bone metastasis model by Raman imaging.Scientific reports · 2022Article
- From Research to Diagnostic Application of Raman Spectroscopy in Neurosciences: Past and Perspectives.Free neuropathology · 2022Article
- Raman Spectroscopy Technique: A Non-Invasive Tool in Celiac Disease Diagnosis.Diagnostics (Basel, Switzerland) · 2021Article
- Identification of amyloid beta in small extracellular vesiclesNanoscale advances · 2021Article
- Article
- GliomaCancers · 2021Article
- Article
- Label-free brain tumor imaging using Raman-based methods.Journal of neuro-oncology · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Raman diagnostics and imaging have been shown to be an effective tool for the analysis and discrimination of human brain tumors from normal structures. Raman spectroscopic methods have potential to be applied in clinical practice as they allow for identification of tumor margins during surgery. In this study, we investigate medulloblastoma (grade IV WHO) (n= 5), low-grade astrocytoma (grades I-II WHO) (n =4), ependymoma (n=3) and metastatic brain tumors (n= 1) and the tissue from the negative margins used as normal controls. We compare a high grade medulloblastoma, low grade astrocytoma and non-tumor samples from human central nervous system (CNS) tissue. Based on the properties of the Raman vibrational features and Raman images we provide a real-time feedback method that is label-free to monitor tumor metabolism that reveals reprogramming of biosynthesis of lipids, proteins, DNA and RNA. Our results indicate marked metabolic differences between low and high grade brain tumors. We discuss molecular mechanisms causing these metabolic changes, particularly lipid alterations in malignant medulloblastoma and low grade gliomas that may shed light on the mechanisms driving tumor recurrence thereby revealing new approaches for the treatment of malignant glioma. We have found that the high-grade tumors of central nervous system (medulloblastoma) exhibit enhanced level of β-sheet conformation and down-regulated level of α-helix conformation when comparing against normal tissue. We have found that almost all tumors studied in the paper have increased Raman signals of nucleic acids. This increase can be interpreted as increased DNA/RNA turnover in brain tumors. We have shown that the ratio of Raman intensities I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.