Evidence map›Paper›PMID 29156704›Full record

ArticleOncotarget2017

ACKR3 expression on diffuse large B cell lymphoma is required for tumor spreading and tissue infiltration.

Viola Puddinu, Sabrina Casella, Egle Radice, Sylvia Thelen, Stefan Dirnhofer, Francesco Bertoni, Marcus Thelen

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Viola PuddinuInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
Sabrina CasellaInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
Egle RadiceInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
Sylvia ThelenInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
Stefan DirnhoferInstitute of Pathology, University Hospital, University of Basel, Basel, Switzerland.
Francesco BertoniInstitute of Oncology Research, Bellinzona, Switzerland.
Marcus ThelenInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
Università della Svizzera italiana · CHInstitute of Oncology Research · CHUniversity of Basel · CHUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diffuse large B cell lymphoma (DLBCL) is the most frequent lymphoma accounting for more than the 30% of the cases. Involvement of extranodal sites, such as bone marrow and central nervous system, is associated with poor prognosis. A contribution of the chemokine system in these processes is assumed as it is known as a critical regulator of the metastatic process in cancer. The atypical chemokine receptor 3 (ACKR3), which does not couple to G-proteins and does not mediate cell migration, acts as a scavenger for CXCL11 and CXCL12, interfering with the tumor homing CXCL12/CXCR4 axis. Here, functional expression of ACKR3 in DLBCL cells was necessary for colonization of the draining lymph node in an

Indexed as

ACKR3B cellchemokineCXCR4lymphoma

Identifiers

PMID29156704
PMCPMC5689594
OpenAlexW2724740174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.