Evidence map›Paper›PMID 29156694›Full record

ArticleOncotarget2017

PDAC-derived exosomes enrich the microenvironment in MDSCs in a

Daniela Basso, Elisa Gnatta, Andrea Padoan, Paola Fogar, Sara Furlanello, Ada Aita, Dania Bozzato, Carlo-Federico Zambon, Giorgio Arrigoni, Chiara Frasson and 8 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Review
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  7. Review
  8. Review
  9. Review
  10. Small extracellular vesicles (sEVs) in pancreatic cancer progression and diagnosis.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Review
  11. Effect of Extracellular Vesicles Derived From Tumor Cells on Immune Evasion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  12. Review
  13. Review
  14. Article
  15. Metabolic features of tumor-derived extracellular vesicles: challenges and opportunities.Extracellular vesicles and circulating nucleic acids · 2024
    Review
  16. Review
  17. Impact of exosome therapy on pancreatic cancer and its progression.Medical oncology (Northwood, London, England) · 2023
    Review
  18. Impact of exosome therapy on pancreatic cancer and its progression.Medical oncology (Northwood, London, England) · 2023
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Daniela BassoDepartment of Medicine - DIMED, University of Padova, Padova, Italy.
Elisa GnattaDepartment of Medicine - DIMED, University of Padova, Padova, Italy.
Andrea PadoanDepartment of Medicine - DIMED, University of Padova, Padova, Italy.
Paola FogarDepartment of Medicine - DIMED, University of Padova, Padova, Italy.
Sara FurlanelloDepartment of Medicine - DIMED, University of Padova, Padova, Italy.
Ada AitaDepartment of Medicine - DIMED, University of Padova, Padova, Italy.
Dania BozzatoDepartment of Medicine - DIMED, University of Padova, Padova, Italy.
Carlo-Federico ZambonDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Giorgio ArrigoniDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Chiara FrassonDepartment of Woman and Child Health, Oncohematology Laboratory, University of Padova, Padova, Italy.
Cinzia FranchinDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Stefania MozDepartment of Medicine - DIMED, University of Padova, Padova, Italy.
Thomas BrefortEurofins Medigenomix GmbH, Ebersberg, Germany.
Thomas LauferComprehensive Biomarker Center GmbH (Recently re-named to Hummingbird Diagnostics GmbH), Heidelberg, Germany.
Filippo NavagliaDepartment of Medicine - DIMED, University of Padova, Padova, Italy.
Sergio PedrazzoliAssociation Wirsung Onlus, Padova, Italy.
Giuseppe BassoDepartment of Woman and Child Health, Oncohematology Laboratory, University of Padova, Padova, Italy.
Mario PlebaniDepartment of Medicine - DIMED, University of Padova, Padova, Italy.
University of Padua · ITAssociazione Italiana Vulvodinia Onlus · ITEurofins (Germany) · DEHummingbird Diagnostics (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor genetics and escape from immune surveillance concur in the poor prognosis of PDAC. In this study an experimental model was set up to verify whether

conclusionPDAC-derived Exo from cells with

Indexed as

calciumexosomesmyeloid derived suppressor cellspancreatic cancerSMAD4

Identifiers

PMID29156694
PMCPMC5689584
OpenAlexW2754472288

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.