Evidence map›Paper›PMID 29156677›Full record

ArticleOncotarget2017

Overcoming resistance to single-agent therapy for oncogenic

Payal Jain, Amanda Silva, Harry J Han, Shih-Shan Lang, Yuankun Zhu, Katie Boucher, Tiffany E Smith, Aesha Vakil, Patrick Diviney, Namrata Choudhari and 11 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 44 citations in OpenAlex.

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  12. Inhibition of RAF dimers: it takes two to tango.Biochemical Society transactions · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 1 country.

Payal JainDivision of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Amanda SilvaDivision of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Harry J HanDepartment of Neurosurgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Shih-Shan LangDivision of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Yuankun ZhuDivision of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Katie BoucherDivision of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Tiffany E SmithDivision of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Aesha VakilThe Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Patrick DivineyDivision of Neurology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Namrata ChoudhariDivision of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Pichai RamanCenter for Data Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Christine M BuschDivision of Oncology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Tim DelaneyDivision of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Xiaodong YangDivision of Neurology, University of California, San Francisco, CA, USA.
Aleksandra K OlowAmgen, South San Francisco, CA, USA.
Sabine MuellerDivision of Neurology, University of California, San Francisco, CA, USA.
Daphne Haas-KoganDepartment of Radiation Oncology, Harvard Medical School, Boston, MA, USA.
Elizabeth FoxDivision of Oncology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Phillip B StormDivision of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Adam C ResnickDivision of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Angela J WaandersCenter for Data Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Children's Hospital of Philadelphia · USUniversity of California, San Francisco · USUniversity of Pennsylvania · USAmgen (United States) · USFred Hutch Cancer Center · USHarvard University · US

Funding

Pediatric low-grade gliomas: biology and molecular targeting.R01NS085336 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI RESNICK, ADAM CAIN · 2014 to 2018
$1.8M
NINDS NIH HHS R01 NS085336
6 · The paper itself

Abstract

Pediatric low-grade gliomas (PLGGs) are frequently associated with activating

Indexed as

BRAF-fusionsMAPK pathwaypediatric low-grade gliomaPI3K/mTOR pathwaytrametinib and everolimus

Identifiers

PMID29156677
PMCPMC5689567
OpenAlexW2754536461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.