Evidence map›Paper›PMID 29156630›Full record

ArticleMolecules (Basel, Switzerland)2017

Anti-Bacteria and Microecosystem-Regulating Effects of Dental Implant Coated with Dimethylaminododecyl Methacrylate.

Bolei Li, Yang Ge, Yao Wu, Jing Chen, Hockin H K Xu, Minggang Yang, Mingyun Li, Biao Ren, Mingye Feng, Michael D Weir and 3 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Microbial Biofilm Decontamination on Dental Implant Surfaces: A Mini Review.Frontiers in cellular and infection microbiology · 2021
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Special Issue: Antibacterial Materials and Coatings.Molecules (Basel, Switzerland) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Bolei LiState Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China. bolei.d.li@gmail.com.
Yang GeState Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China. yang_ge_dentist@hotmail.com.
Yao WuNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. wuyao@scu.edu.cn.
Jing ChenState Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China. sallychen.jc@gmail.com.
Hockin H K XuDepartment of Advanced Oral Sciences & Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA. Hxu@umaryland.edu.
Minggang YangNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. minggang_yang@163.com.
Mingyun LiState Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China. limingyun@scu.edu.cn.
Biao RenState Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China. renbiao@scu.edu.cn.
Mingye FengState Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China. fengmingye@gmail.com.
Michael D WeirDepartment of Advanced Oral Sciences & Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA. MWeir@umaryland.edu.
Xian PengState Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China. pengx@scu.edu.cn.
Lei ChengState Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China. chenglei@scu.edu.cn.
Xuedong ZhouState Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China. zhouxd@scu.edu.cn.
Sichuan University · CNUniversity of Maryland, Baltimore · US

Funding

Development of high performance, caries-inhibiting dental nano-materialsR01DE017974 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI XU, HUAKUN · 2008 to 2011
$1.0M
NIDCR NIH HHS R01 DE017974
6 · The paper itself

Abstract

The effects of dimethylaminododecyl methacrylate (DMADDM) modified titanium implants on bacterial activity and microbial ecosystem of saliva-derived biofilm were investigated for the first time. Titanium discs were coated with DMADDM solutions at mass fractions of 0 mg/mL (control), 1, 5 and 10 mg/mL, respectively. Biomass accumulation and metabolic activity of biofilms were tested using crystal violet assay and MTT (3-(4,5-Dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. 16S rRNA gene sequencing was performed to measure the microbial community. Live/dead staining and scanning electron microscopy (SEM) were used to value the structure of biofilm. The results showed that the higher mass fraction of DMADDM the coating solution had, the significantly lower the values of metabolic activity and accumulated biofilms got, as well as fewer live cells and less extracellular matrix. Moreover, 5 mg/mL of DMADDM was the most effective concentration, as well as 10 mg/mL. In microecosystem-regulation, the DMADDM modified titanium implant decreased the relative abundance of

Indexed as

Dental ImplantsAnti-Bacterial AgentsBiofilmsMethacrylatesQuaternary Ammonium CompoundsStreptococcus mutansAnti-Bacterial AgentsDental Implantsdimethylaminododecyl methacrylateMethacrylatesQuaternary Ammonium Compoundsantimocrobial materialdental implantdimethylaminododecyl methacrylateperi-implant diseasessaliva-derived biofilm

Identifiers

PMID29156630
PMCPMC6150392
OpenAlexW2770046723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.