Evidence map›Paper›PMID 29156609›Full record

ReviewInternational journal of molecular sciences2017

Green Routes for the Production of Enantiopure Benzylisoquinoline Alkaloids.

Francesca Ghirga, Alessandra Bonamore, Lorenzo Calisti, Ilaria D'Acquarica, Mattia Mori, Bruno Botta, Alberto Boffi, Alberto Macone

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Genome-Wide Identification and Functional Verification of CoreInternational journal of molecular sciences · 2026
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  2. Review
  3. Transcriptome Analysis ofMolecules (Basel, Switzerland) · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Francesca GhirgaCenter for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy. francesca.ghirga@uniroma1.it.
Alessandra BonamoreDeaprtment of Biochemical Sciences "A.Rossi Fanelli", Sapienza University of Rome, Pizzale Aldo Moro 5, 00185 Rome, Italy. alessandra.bonamore@uniroma1.it.
Lorenzo CalistiDeaprtment of Biochemical Sciences "A.Rossi Fanelli", Sapienza University of Rome, Pizzale Aldo Moro 5, 00185 Rome, Italy. Lorenzo.calisti@uniroma1.it.
Ilaria D'AcquaricaDepartment of Chemistry and Technology of Drugs, Sapienza University of Rome, Pizzale Aldo Moro 5, 00185 Rome, Italy. ilaria.dacquarica@uniroma1.it.
Mattia MoriCenter for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy. mattia.mori@iit.it.
Bruno BottaDepartment of Chemistry and Technology of Drugs, Sapienza University of Rome, Pizzale Aldo Moro 5, 00185 Rome, Italy. bruno.botta@uniroma1.it.ORCID 0000-0001-8707-4333
Alberto BoffiDeaprtment of Biochemical Sciences "A.Rossi Fanelli", Sapienza University of Rome, Pizzale Aldo Moro 5, 00185 Rome, Italy. alberto.boffi@uniroma1.it.ORCID 0000-0003-0455-1400
Alberto MaconeDeaprtment of Biochemical Sciences "A.Rossi Fanelli", Sapienza University of Rome, Pizzale Aldo Moro 5, 00185 Rome, Italy. alberto.macone@uniroma1.it.
Sapienza University of Rome · ITItalian Institute of Technology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Benzylisoquinoline alkaloids (BIAs) are among the most important plant secondary metabolites, in that they include a number of biologically active substances widely employed as pharmaceuticals. Isolation of BIAs from their natural sources is an expensive and time-consuming procedure as they accumulate in very low levels in plant. Moreover, total synthesis is challenging due to the presence of stereogenic centers. In view of these considerations, green and scalable methods for BIA synthesis using fully enzymatic approaches are getting more and more attention. The aim of this paper is to review fully enzymatic strategies for producing the benzylisoquinoline central precursor, (

Indexed as

BioreactorsAlkaloidsBacteriaBenzylisoquinolinesEscherichia coliPlantsRecombinant ProteinsSaccharomyces cerevisiaeTetrahydroisoquinolinesAlkaloidsBenzylisoquinolineshigenamineRecombinant ProteinsTetrahydroisoquinolinesalkaloidsbenzylisoquinoline alkaloidsgreen synthesismicrobial factoriesrecombinant enzymes

Identifiers

PMID29156609
PMCPMC5713430
OpenAlexW2768771151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.