ArticleNutrients2017
WNT Inhibitory Activity of Malus Pumila miller cv Annurca and Malus domestica cv Limoncella Apple Extracts on Human Colon-Rectal Cells Carrying Familial Adenomatous Polyposis Mutations.
Article in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Apple oil as a source of ursolic acid for the treatment of hyperpigmentary disorders with molecular and clinical evaluation.Scientific reports · 2025Trial
- Multivariate Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from Apples.Molecules (Basel, Switzerland) · 2026Article
- Cytoprotective Potential ofInternational journal of molecular sciences · 2025Article
- Chemical Profile and Promising Applications ofAntioxidants (Basel, Switzerland) · 2024Article
- NAD-Driven Sirtuin Activation byInternational journal of molecular sciences · 2024Article
- Polyphenol-Rich Extract from 'Limoncella' Apple Variety Ameliorates Dinitrobenzene Sulfonic Acid-Induced Colitis and Linked Liver Damage.International journal of molecular sciences · 2024Article
- Natural Chalcones for the Management of Obesity Disease.International journal of molecular sciences · 2023Review
- Optimization of Ursolic Acid Extraction in Oil from Annurca Apple to Obtain Oleolytes with Potential Cosmeceutical Application.Antioxidants (Basel, Switzerland) · 2023Article
- Genotoxic Assessment of Nutraceuticals Obtained from Agricultural Biowaste: Where Do We "Antioxidants (Basel, Switzerland) · 2022Review
- Genotoxicity Assessment of Three Nutraceuticals Containing Natural Antioxidants Extracted from Agri-Food Waste Biomasses.Foods (Basel, Switzerland) · 2020Article
- The Hepatoprotective Effect of Taurisolo, a Nutraceutical Enriched in Resveratrol and Polyphenols, Involves Activation of Mitochondrial Metabolism in Mice Liver.Antioxidants (Basel, Switzerland) · 2020Article
- Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives.Cells · 2020Review
- Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells.Nutrients · 2019Article
- A Boost in Mitochondrial Activity Underpins the Cholesterol-Lowering Effect of Annurca Apple Polyphenols on Hepatic Cells.Nutrients · 2019Article
- Medicinal Plants in the Prevention and Treatment of Colon Cancer.Oxidative medicine and cellular longevity · 2019Review
- Article
- Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation.Nutrients · 2018Article
- Effects of Polyphenol-Rich Foods on Human Health.Nutrients · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inhibitors of the Wingless-related Integration site (WNT)/β-catenin pathway have recently been under consideration as potential chemopreventive agents against Familial Adenomatous Polyposis (FAP). This autosomal-dominant syndrome is caused by germline mutations in the gene coding for the protein APC and leads to hyperactivation of the WNT/β-catenin signaling pathway, uncontrolled intestinal cell proliferation and formation of adenocarcinomas. The aim of the present work was to: (i) test, on in vitro cultures of cells carrying FAP mutations and on ex vivo biopsies of FAP patients, the WNT inhibitory activity of extracts from two common southern Italian apples,
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.