Evidence map›Paper›PMID 29156185›Full record

ReviewThe Medical clinics of North America2018

Maintenance of Lost Weight and Long-Term Management of Obesity.

Kevin D Hall, Scott Kahan

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Medical clinics of North America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05162001 (Body Weight Response With Disulfiram in Humans. Concept Testing Study), which is not on this map. Cited by 443 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
443citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05162001 early_phase1unknown statusnot on this mapstarted 2021, after this paper: background citation

Body Weight Response With Disulfiram in Humans. Concept Testing Study

TypeinterventionalSponsorUniversidad de GuanajuatoRan2021 to 2022Enrolled10ConditionsObesity, DrugArmsDisulfiram 250 mg
3 · Its place in the literature

Who cites it

443 citing papers in PubMed, 12 syntheses or guidelines pooled it.

  1. Are There Any Effective Behavior Change Strategies for Communicating Genetic Risk in Obesity Prevention and Body Weight Reduction Interventions?Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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  11. Emotional Eating Interventions for Adults Living With Overweight and Obesity: A Systematic Review and Meta-Analysis of Behaviour Change Techniques.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025
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383 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kevin D HallNational Institute of Diabetes and Digestive and Kidney Diseases, 12A South Drive, Room 4007, Bethesda, MD 20892, USA. Electronic address: kevinh@niddk.nih.gov.
Scott KahanJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; George Washington University School of Medicine, 1020 19th Street NW, Suite 450, Washington, DC 20036, USA.

Funding

Modeling interactions of diet, exercise, metabolism, and weight change in humansZIADK013037 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI DARCEY, VALERIE · 2009 to 2025
$10.8M
Computational modeling of human metabolism, body weight and compositionZIADK013036 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HALL, KEVIN · 2009 to 2024
$3.6M
Intramural NIH HHS ZIA DK013036Intramural NIH HHS ZIA DK013037
6 · The paper itself

Abstract

Weight loss can be achieved through a variety of modalities, but long-term maintenance of lost weight is much more challenging. Obesity interventions typically result in early weight loss followed by a weight plateau and progressive regain. This review describes current understanding of the biological, behavioral, and environmental factors driving this near-ubiquitous body weight trajectory and the implications for long-term weight management. Treatment of obesity requires ongoing clinical attention and weight maintenance-specific counseling to support sustainable healthful behaviors and positive weight regulation.

Indexed as

Diet, ReducingRisk Reduction BehaviorAdaptation, PhysiologicalEnergy MetabolismHealth PromotionHumansObesitySelf CareWeight GainAppetiteBehavioral counselingObesity treatmentPhysiologyWeight lossWeight maintenance

Identifiers

PMID29156185
PMCPMC5764193

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.