ArticleRadiology2018
CM-101: Type I Collagen-targeted MR Imaging Probe for Detection of Liver Fibrosis.
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Article in Radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40citing papers in PubMed
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40 citing papers in PubMed, 63 citations in OpenAlex.
- Unmasking Early Hepatorenal Fibrosis in Polycystic Kidney Disease Using Noninvasive Precision Molecular MRI of Collagen.bioRxiv : the preprint server for biology · 2026Article
- Early detection of invasive lung cancer and multiorgan metastasis by a collagen-targeted protein MRI contrast agent.Science advances · 2026Article
- Molecular MRI of Collagen Enables Evaluation of Fibrosis and Therapeutic Response in Venous Thrombosis.Circulation. Cardiovascular imaging · 2026Article
- Affibody-based optical imaging probe for noninvasive detection of liver fibrosis.Theranostics · 2026Article
- Transcriptomic Changes Underlying the Anti-Steatotic Effects of DHA Supplementation in Aged Obese Female Mice.International journal of molecular sciences · 2025Article
- Fibrotic Disease: from Signaling Pathways and Biomarkers to Molecular Imaging.Molecular imaging and biology · 2025Review
- Differential extracellular matrix proteomic signatures in colorectal tumors from Appalachian and non-Appalachian patients.Oncology letters · 2025Article
- Manganese-based type I collagen-targeting MRI probe for in vivo imaging of liver fibrosis.Npj imaging · 2025Article
- Spatial localization of collagen hydroxylated proline site variation as an ancestral trait in the breast cancer microenvironment.Matrix biology : journal of the International Society for Matrix Biology · 2025Article
- Collagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Non-invasive diagnosis of liver fibrosis via MRI using targeted gadolinium-based nanoparticles.European journal of nuclear medicine and molecular imaging · 2024Article
- Non-invasive in vivo imaging of changes in Collagen III turnover in myocardial fibrosis.Npj imaging · 2024Article
- Collagen type I PET/MRI enables evaluation of treatment response in pancreatic cancer in pre-clinical and first-in-human translational studies.Theranostics · 2024Article
- Advances in Noninvasive Molecular Imaging Probes for Liver Fibrosis Diagnosis.Biomaterials research · 2024Review
- Detection of Endometriosis Lesions Using Gd-Based Collagen I Targeting Probe in Murine Models of Endometriosis.Molecular imaging and biology · 2023Article
- Biased Quantification of Rat Liver Fibrosis-Meta-Analysis with Practical Recommendations and Clinical Implications.Journal of clinical medicine · 2023Article
- Early Detection and Staging of Lung Fibrosis Enabled by Collagen-Targeted MRI Protein Contrast Agent.Chemical & biomedical imaging · 2023Article
- Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles viaProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Multimodality Advanced Cardiovascular and Molecular Imaging for Early Detection and Monitoring of Cancer Therapy-Associated Cardiotoxicity and the Role of Artificial Intelligence and Big Data.Frontiers in cardiovascular medicine · 2022Review
- Emerging MRI techniques for molecular and functional phenotyping of the diseased heart.Frontiers in cardiovascular medicine · 2022Review
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Authors and funding
20 authors at 5 institutions in 1 country.
Christian T FarrarFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Eric M GaleFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Richard KennanFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Ian RamsayFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Ricard MasiaFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Gunisha AroraFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Kailyn LoobyFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Lan WeiFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Jayashree Kalpathy-CramerFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Michelle M BunzelFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Chunlian ZhangFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Yonghua ZhuFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Taro E AkiyamaFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Michael KlimasFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Shirly PintoFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Himashinie DiyabalanageFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Kenneth K TanabeFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Valerie HumbletFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Bryan C FuchsFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Peter CaravanFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129 (C.T.F., E.M.G., I.R., J.K., P.C.); Merck Research Laboratories, Kenilworth, NJ (R.K., M.M.B., C.Z., Y.Z., T.E.A., M.K., S.P.); Collagen Medical, Belmont, Mass (I.R., H.D., V.H.); Departments of Pathology (R.M.) and Surgical Oncology (G.A., K.L., L.W., K.K.T., B.C.F.), Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Mass; and Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (P.C.).
Harvard University · USMassachusetts General Hospital · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USCollagen Medical (United States) · USAthinoula A. Martinos Center for Biomedical Imaging · US
Funding
ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 1999 to 2011
$16.4MMolecular Imaging of Liver FibrosisR01DK104956 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI TANABE, KENNETH K · 2015 to 2019
$2.7MOptimization of Efficacy and Safety Pharamacology of Fibrosis Imaging Agent CM-65R44DK095617 · NIDDK · COLLAGEN MEDICAL, LLC · PI DIYABALANAGE, HIMASHINIE · 2012 to 2014
$1.4M500 MHz NMR Spectrometer for Molecular Imaging ApplicationsS10RR023385 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2007 to 2007
$500kHPLC-ICP-MS SystemS10OD010650 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2013 to 2013
$371kNCRR NIH HHS P41 RR014075NCRR NIH HHS S10 RR023385NIDDK NIH HHS R01 DK104956NIDDK NIH HHS R44 DK095617NIH HHS S10 OD010650
Abstract
Purpose To evaluate the biodistribution, metabolism, and pharmacokinetics of a new type I collagen-targeted magnetic resonance (MR) probe, CM-101, and to assess its ability to help quantify liver fibrosis in animal models. Materials and Methods Biodistribution, pharmacokinetics, and stability of CM-101 in rats were measured with mass spectrometry. Bile duct-ligated (BDL) and sham-treated rats were imaged 19 days after the procedure by using a 1.5-T clinical MR imaging unit. Mice were treated with carbon tetrachloride (CCl
Indexed as
Magnetic Resonance ImagingAnimalsCarbon TetrachlorideDisease Models, AnimalFibrosisGadoliniumHalf-LifeLiverLiver CirrhosisMass SpectrometryMicePolysaccharides, BacterialRatsTissue DistributionCarbon TetrachlorideGadoliniumPolysaccharides, Bacterialstreptococcal polysaccharide type III group B
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