Evidence map›Paper›PMID 29156135›Full record

ReviewACS chemical biology2018

Fluorescent Probes of DNA Repair.

David L Wilson, Eric T Kool

Abstract readReview
In one paragraph

Review in ACS chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Deciphering the aging process through single-cell cytometric technologies.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2024
    Review
  4. Rationally Designed DNA-Based Scaffolds and Switching Probes for Protein Sensing.Advances in biochemical engineering/biotechnology · 2024
    Review
  5. Chemical Insights into Oxidative and Nitrative Modifications of DNA.International journal of molecular sciences · 2023
    Review
  6. Rationalizing the environment-dependent photophysical behavior of a DNA luminescent probe by classical and non-adiabatic molecular dynamics simulations.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023
    Article
  7. Article
  8. Chemical Tools for the Study of DNA Repair.Accounts of chemical research · 2022
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. An Excimer Clamp for Measuring Damaged-Base Excision by the DNA Repair Enzyme NTH1.Angewandte Chemie (International ed. in English) · 2020
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

David L WilsonDepartment of Chemistry , Stanford University , Stanford , California 94305 , United States.ORCID 0000-0002-1922-427X
Eric T KoolDepartment of Chemistry , Stanford University , Stanford , California 94305 , United States.ORCID 0000-0002-7310-2935

Funding

Measuring and Modulating Oxidative DNA Damage Surveillance PathwaysR01CA217809 · NCI · STANFORD UNIVERSITY · PI KOOL, ERIC T. · 2017 to 2024
$3.7M
Highly Reactive Hydrazone Chemistry: Orthogonal Modification in Cellular ContextsR01GM110050 · NIGMS · STANFORD UNIVERSITY · PI KOOL, ERIC T. · 2015 to 2018
$1.2M
DNA-carbon Assemblies for Multispectral ImagingR01GM106067 · NIGMS · STANFORD UNIVERSITY · PI KOOL, ERIC T. · 2014 to 2017
$1.2M
NCI NIH HHS R01 CA217809NIGMS NIH HHS R01 GM106067NIGMS NIH HHS R01 GM110050
6 · The paper itself

Abstract

DNA repair is now understood to play a key role in a variety of disease states, most notably cancer. Tools for studying DNA have typically relied on traditional biochemical methods which are often laborious and indirect. Efforts to study the biology and therapeutic relevance of DNA repair pathways can be limited by such methods. Recently, specific fluorescent probes have been developed to aid in the study of DNA repair. Fluorescent probes offer the advantage of being able to directly assay for DNA repair activity in a simple, mix-and-measure format. This review will summarize the distinct classes of probe designs and their potential utility in varied research and preclinical settings.

Indexed as

DNA RepairDNADNA Repair EnzymesFluorescent DyesHumansDNADNA Repair EnzymesFluorescent Dyes

Identifiers

PMID29156135
PMCPMC5976523

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.