Evidence map›Paper›PMID 29155870›Full record

ArticlePloS one2017

A modified Delphi study to determine the level of consensus across the European Union on the structures, processes and desired outcomes of the management of polypharmacy in older people.

Derek Stewart, Kathrine Gibson-Smith, Katie MacLure, Alpana Mair, Albert Alonso, Carles Codina, Antonio Cittadini, Fernando Fernandez-Llimos, Glenda Fleming, Dimitra Gennimata and 11 more

Abstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  17. Development of a framework for the collaborative adaptation of service models for child and family health in diverse settings (CASCADES).Journal of child health care : for professionals working with children in the hospital and community · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Derek StewartSchool of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, Scotland, United Kingdom.ORCID http://orcid.org/0000-0001-7360-8592
Kathrine Gibson-SmithSchool of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, Scotland, United Kingdom.
Katie MacLureSchool of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, Scotland, United Kingdom.
Alpana MairEffective Prescribing and Therapeutics, Health and Social Care Directorate, Scottish Government, Edinburgh, Scotland, United Kingdom.
Albert AlonsoDirectorate of Research and Innovation, Fundació Clínic per a la Recerca Biomèdica (FCRB), Barcelona, Spain.
Carles CodinaPharmacy Department, Hospital Clínic de Barcelona, Barcelona, Spain.
Antonio CittadiniDepartment of Translational Medical Sciences, University Federico II, Naples, Italy.
Fernando Fernandez-LlimosInstitute for Medicines Research (iMed.Ulisboa), Department of Social Pharmacy, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal.
Glenda FlemingMedicines Optimisation Innovation Centre, Northern Health & Social Care Trust, Belfast, Northern Ireland.
Dimitra GennimataDepartment of Social and Educational Policy, University of Peloponnese, Corinthos, Greece.
Ulrika GillespiePharmacy Department, Uppsala University Hospital, Uppsala, Sweden.
Cathy HarrisonDepartment of Health Social Services and Public Safety, Belfast, Northern Ireland.
Ulrike Junius-WalkerInstitute for General Medicine, Medizinische Hochschule Hannover, Hannover, Germany.
Przemysław KardasDepartment of Family Medicine, Medical University of Lodz, Lodz, Poland.
Thomas KempenPharmacy Department, Uppsala University Hospital, Uppsala, Sweden.
Moira KinnearNHS Lothian Pharmacy Service, Western General Hospital, Edinburgh, Scotland, United Kingdom.
Pawel LewekDepartment of Family Medicine, Medical University of Lodz, Lodz, Poland.
Joao MalvaFaculty of Medicine, University of Coimbra, Coimbra, Portugal.
Jennifer McIntoshDirectorate of Research and Innovation, Fundació Clínic per a la Recerca Biomèdica (FCRB), Barcelona, Spain.
Claire ScullinSchool of Pharmacy, Queen's University, Belfast, Northern Ireland, United Kingdom.
Birgitt WieseInstitute for General Medicine, Medizinische Hochschule Hannover, Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInappropriate use of multiple medicines (inappropriate polypharmacy) is a major challenge in older people with consequences of increased prevalence and severity of adverse drug reactions and interactions, and reduced medicines adherence. The aim of this study was to determine the levels of consensus amongst key stakeholders in the European Union (EU) in relation to aspects of the management of polypharmacy in older people.

methodsForty-six statements were developed on aspects of healthcare structures, processes and desired outcomes, with consensus defined at ≥ 80% agreement. Panel members were strategists (e.g. directors, leading clinicians and commissioners) from each of the 28 EU member states, with a target recruitment of five per member state. Three Delphi rounds were conducted via email, with panel members being provided with summative results and collated, anonymised comments at the commencement of Rounds 2 and 3.

resultsNinety panel members were recruited (64.3% of target), with high participation levels throughout the three Delphi rounds (91.1%, 83.3%, 72.2%). During Round 1, consensus was obtained for 27/46 statements (58.7%), with an additional two statements in Round 2 and none in Round 3. Consensus was obtained for statements relating to: potential gain arising from polypharmacy management (3/4 statements); strategic development (7/7); change management (5/7) indicator measures (4/6); legislation (0/3); awareness raising (5/5); polypharmacy reviews (5/7); and EU vision (0/7). Analysis of free text comments indicated that the vision statements were too ambitious and not achievable by the specified timeframe of 2025.

conclusionConsensus was obtained amongst key EU strategists around many aspects of polypharmacy management in older people. Notably, no consensus was achieved in relation to statements relating to the need to alter legislation in areas of healthcare delivery, remuneration and practitioner scope of practice. While the vision for the EU by 2025 was considered rather ambitious, there is great potential and clear opportunity to advance polypharmacy management throughout the EU and beyond.

Indexed as

ConsensusPolypharmacyAgedAged, 80 and overDelivery of Health CareDelphi TechniqueDrug MonitoringDrug-Related Side Effects and Adverse ReactionsEuropean UnionFemaleHumansMaleMedication Adherence

Identifiers

PMID29155870
PMCPMC5695766

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.