ArticlePloS one2017
Pancreatic exocrine insufficiency in patients with chronic heart failure and its possible association with appetite loss.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence-based recommendations.United European gastroenterology journal · 2025Guideline
- Chronic pancreatitis and the heart disease: Still terra incognita?World journal of gastroenterology · 2019Pooled it
- Burden of non-cancer comorbidities and mortality in chronic pancreatitis: a retrospective cohort study.BMJ open gastroenterology · 2026Article
- The cardio-pancreatic axis in heart failure: from conceptual framework to empirical evidence.ESC heart failure · 2026Article
- Heart failure with preserved ejection fraction beyond the heart: exploring the heart-liver-pancreas axis.ESC heart failure · 2026Review
- Heart failure with preserved ejection fraction as a systemic inflammatory-metabolic disorder: through the cardio-hepato-pancreatic axis lens.Frontiers in cardiovascular medicine · 2026Article
- Recent Advances in Biomolecular Patho-Mechanistic Pathways behind the Development and Progression of Diabetic Neuropathy.Biomedicines · 2024Review
- Geriatric Nutritional Risk Index Predicts High Activities of Daily Living at Discharge in Older Patients with Heart Failure after Cardiac Rehabilitation.Journal of clinical medicine · 2023Article
- Association of Cardiovascular Disease and Pancreatitis: What Came First, the Chicken or the Egg?Journal of clinical medicine · 2023Review
- Association between right heart catheterization hemodynamics and glycosylated hemoglobin levels in adults with heart failure with reduced ejection fraction.Cardiovascular endocrinology & metabolism · 2023Article
- Systemic mapping of organ plasma extravasation at multiple stages of chronic heart failure.Frontiers in physiology · 2023Article
- Heart Failure and Pancreas Exocrine Insufficiency: Pathophysiological Mechanisms and Clinical Point of View.Journal of clinical medicine · 2022Review
- Associations with pancreatic exocrine insufficiency: An United Kingdom single-centre study.World journal of clinical cases · 2021Article
- Appetite and Nutritional Status as Potential Management Targets in Patients with Heart Failure with Reduced Ejection Fraction-The Relationship between Echocardiographic and Biochemical Parameters and Appetite.Journal of personalized medicine · 2021Article
- Exocrine pancreatic insufficiency: prevalence, diagnosis, and management.Clinical and experimental gastroenterology · 2019Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAppetite loss is one complication of chronic heart failure (CHF), and its association with pancreatic exocrine insufficiency (PEI) is not well investigated in CHF.
aimWe attempted to detect the association between PEI and CHF-induced appetite.
methodsPatients with CHF were enrolled, and body mass index (BMI), left ventricular ejection fraction (LVEF), New York Heart Association (NYHA) cardiac function grading, B-type natriuretic peptide (BNP), serum albumin, pro-albumin and hemoglobin were evaluated. The pancreatic exocrine function was measured by fecal elastase-1 (FE-1) levels in the enrolled patients. Appetite assessment was tested by completing the simplified nutritional appetite questionnaire (SNAQ). The improvement of appetite loss by supplemented pancreatic enzymes was also researched in this study.
resultsThe decrease of FE-1 levels was found in patients with CHF, as well as SNAQ scores. A positive correlation was observed between SNAQ scores and FE-1 levels (r = 0.694, p < 0.001). Pancreatic enzymes supplement could attenuate the decrease of SNAQ scores in CHF patients with FE-1 levels <200 μg/g stool and SNAQ < 14.
conclusionsAppetite loss is commonly seen in CHF, and is partially associated with pancreatic exocrine insufficiency. Oral pancreatic enzyme replacement therapy attenuates the chronic heart failure-induced appetite loss. These results suggest a possible pancreatic-cardiac relationship in chronic heart failure, and further experiment is needed for clarifying the possible mechanisms.
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