ArticlePloS one2017
Pre-pubertal exposure with phthalates and bisphenol A and pubertal development.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Phenols, Parabens, Phthalates and Puberty: a Systematic Review of Synthetic Chemicals Commonly Found in Personal Care Products and Girls' Pubertal Development.Current environmental health reports · 2022Pooled it
- Prenatal and postnatal exposures to endocrine disrupting chemicals and timing of pubertal onset in girls and boys: a systematic review and meta-analysis.Human reproduction update · 2022Pooled it
- Phthalate exposure and female reproductive and developmental outcomes: a systematic review of the human epidemiological evidence.Environment international · 2019Pooled it
- IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: Phthalates disrupt female reproductive health: a call for enhanced investigation into mixtures.Reproduction (Cambridge, England) · 2025Review
- Exposure of elementary school-aged Brazilian children to bisphenol A: association with demographic, social, and behavioral factors, and a worldwide comparison.Scientific reports · 2024Article
- Longitudinal association of prepubertal urinary phthalate metabolite concentrations with pubertal progression among a cohort of boys.Environmental research · 2023Article
- PFAS and Phthalate/DINCH Exposure in Association with Age at Menarche in Teenagers of the HBM4EU Aligned Studies.Toxics · 2023Article
- Impact of Chemicals on the Age of Menarche: A Literature Review.Children (Basel, Switzerland) · 2023Review
- Secondary oxidized di-2-ethylhexyl phthalate metabolites may be associated with progression from isolated premature thelarche to central precocious or early puberty.Scientific reports · 2023Article
- Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs.EFSA journal. European Food Safety Authority · 2023Article
- Chemical Effects on Breast Development, Function, and Cancer Risk: Existing Knowledge and New Opportunities.Current environmental health reports · 2022Review
- Associations of prepubertal urinary phthalate metabolite concentrations with pubertal onset among a longitudinal cohort of boys.Environmental research · 2022Article
- Housing Environment Affects Pubertal Onset, Anxiety-like Behavior, and Object Interaction in Male and Female Long Evans Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Comparing adolescent self staging of pubertal development with hormone biomarkers.Journal of pediatric endocrinology & metabolism : JPEM · 2021Article
- Role of epidemiology in risk assessment: a case study of five ortho-phthalates.Environmental health : a global access science source · 2021Article
- Identifying environmental exposure profiles associated with timing of menarche: A two-step machine learning approach to examine multiple environmental exposures.Environmental research · 2021Article
- Association of phthalates and early menarche in Korean adolescent girls from Korean National Environmental Health Survey (KoNEHS) 2015-2017.Annals of occupational and environmental medicine · 2021Article
- Effects and Mechanisms of Phthalates' Action on Reproductive Processes and Reproductive Health: A Literature Review.International journal of environmental research and public health · 2020Review
- Safeguarding Female Reproductive Health against Endocrine Disrupting Chemicals-The FREIA Project.International journal of molecular sciences · 2020Review
- Onset and tempo of sexual maturation is differentially associated with gestational phthalate exposure between boys and girls in a Mexico City birth cohort.Environment international · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEpidemiological studies indicate associations between childhood exposure with phthalates and bisphenol A (BPA) and the pubertal development. We examined associations between the pre-pubertal phthalate and BPA body burden and the longitudinally assessed sexual maturation of eight- to thirteen-year-old children.
methodsWe started with eight- to ten-year-old children in the baseline study and quantified phthalate metabolites and BPA in 472 urine samples (250 boys; 222 girls; mean age: 8.8 years). Associations between the pubertal development, assessed in three annual follow-up studies by Puberty Development scale questionnaires (PD scales), and the chemical exposure from the baseline visit were longitudinally analyzed with generalized estimation equations.
resultsThe number of children with both chemical measures and PD scores (calculated from the PD scales) was 408. In the third follow-up, 49% of the girls and 18% of the boys had reached mid-puberty. For girls, we observed a delayed pubertal development with the di-hexyl-ethyl phthalate (DEHP) metabolites (β: -0.16 to -0.23; p ≤ 0.05 or p ≤ 0.1), mono-n-butyl phthalate (β: -0.15; 95% CI: -0.31; 0.01), mono-benzyl phthalate (β: -0.11; 95% CI: -0,24; -0,01), and mono-ethyl phthalate (MEP) (β: -0.15; 95% CI: -0.28; -0.01). In addition, significant non-linear associations of the DEHP metabolites and BPA with the PD scores were found, when their quadratic effects were included in the GEE models. In boys, no consistent relationships between the PD scores and the chemicals were detected except of an accelerated development with the ∑DEHP metabolites (β: 0.16; 95% CI: -0.02; -0.34).
conclusionWe found indications that pre-pubertal exposures with phthalates and BPA were associated with pubertal timing in children, particularly in girls. For boys, associations were inconsistent, and not necessarily in line with the known anti-androgenicity of some phthalates during prenatal exposure.
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