ArticlePLoS neglected tropical diseases2017
Prevalence and risk factors associated with Leishmania infection in Trang Province, southern Thailand.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Prevalence of visceral leishmaniasis among people with HIV: a systematic review and meta-analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Pooled it
- Phlebotomine sand flies (Diptera: Psychodidae) and sand fly-borne pathogens in the Greater Mekong Subregion: a systematic review.Parasites & vectors · 2022Pooled it
- Integrative morphological and DNA barcoding analysis of Forcipomyia (Lasiohelea) midges: cryptic diversity and first molecular detection of multiple Leishmania species in a leishmaniasis-endemic focus in Southern Thailand.Parasites & vectors · 2026Article
- Epidemiology of malaria and leishmaniasis in Thailand (2004-2025): A systematic review.Current research in parasitology & vector-borne diseases · 2026Review
- Analysis of Phlebotomine sandflies in Laos from 2014-2024: Inventory, description of a new species, screening for Leishmania and detection of Trypanosoma.PLoS neglected tropical diseases · 2026Article
- Identification of Tripeptide Inhibitors Targeting MAPK3 inACS omega · 2025Article
- Screening for visceral leishmaniasis in humans and animals in Laos.Tropical medicine and health · 2025Article
- Prevalence of Leishmania infection in refugee camps: A serological and molecular study in Gambella and Benishangul-Gumuz, Ethiopia.PLoS neglected tropical diseases · 2025Article
- DNA barcoding of Culicoides biting midges (Diptera: Ceratopogonidae) and detection of Leishmania and other trypanosomatids in southern Thailand.Parasites & vectors · 2025Article
- A one-step multiplex qPCR assay for simultaneous identification and quantification of Leishmania martiniquensis and Leishmania orientalis/Leishmania chancei and detection and quantification of trypanosomatids in clinical samples.Parasite (Paris, France) · 2025Article
- Genome analyses of amphotericin B-susceptible and -resistant strains ofCurrent research in parasitology & vector-borne diseases · 2025Article
- An update onParasite epidemiology and control · 2024Review
- Asymptomatic Leishmania Infection among Blood Donors in a Southern Province of Thailand.The American journal of tropical medicine and hygiene · 2024Article
- Incidence and persistence of asymptomatic Leishmania infection among HIV-infected patients in Trang province, Southern Thailand: A cohort study.PLoS neglected tropical diseases · 2024Article
- Seasonal dynamics, Leishmania diversity, and nanopore-based metabarcoding of blood meal origins in Culicoides spp. in the newly emerging focus of leishmaniasis in Northern Thailand.Parasites & vectors · 2024Article
- Leishmania Infection among HIV-Infected Patients in a Southern Province of Thailand: A Cross-Sectional Study.The American journal of tropical medicine and hygiene · 2024Article
- Nanopore-Based Surveillance ofInsects · 2024Article
- Steppe lemmings and Chinese hamsters as new potential animal models for the study of the Leishmania subgenus Mundinia (Kinetoplastida: Trypanosomatidae).PLoS neglected tropical diseases · 2024Article
- Atypical cutaneous leishmaniasis: a new challenge to VL elimination in South-East Asia.Frontiers in cellular and infection microbiology · 2024Review
- Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutochthonous cutaneous and visceral leishmaniasis (VL) caused by Leishmania martiniquensis and Leishmania siamensis have been considered emerging infectious diseases in Thailand. The disease burden is significantly underestimated, especially the prevalence of Leishmania infection among HIV-positive patients.
methodsA cross-sectional study was conducted to determine the prevalence and risk factors associated with Leishmania infection among patients with HIV/AIDS living in Trang province, southern Thailand, between 2015 and 2016. Antibodies against Leishmania infection were assayed using the direct agglutination test (DAT). DNA of Leishmania was detected by ITS1-PCR using the buffy coat. Species of Leishmania were also identified.
resultsOf 724 participants, the prevalence of Leishmania infection was 25.1% (182/724) using either DAT or PCR assays. Seroprevalence of Leishmania infection was 18.5% (134/724), while Leishmania DNA detected by the PCR method was 8.4% (61/724). Of these, 24.9% (180/724) were asymptomatic, whereas 0.3% (2/724) were symptomatic VL and VL/CL (cutaneous leishmaniasis). At least five species were identified: L. siamensis, L. martiniquensis, L. donovani complex, L. lainsoni, and L. major. Multivariate analysis showed that CD4+ levels <500 cells/μL and living in stilt houses were independently associated with Leishmania infection. Those who were PCR positive for Leishmania DNA were significantly associated with a detectable viral load, whereas non-injection drug use (NIDU) and CD4+ levels <500 cells/μL were potential risk factors of Leishmania seropositivity.
conclusionsA magnitude of the prevalence of underreporting Leishmania infection among Thai patients with HIV was revealed in this study. Effective public health policy to prevent and control disease transmission is urgently needed.
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