Evidence map›Paper›PMID 29155492›Full record

ArticleAutism research : official journal of the International Society for Autism Research2018

The prevalence of gluten free diet use among preschool children with autism spectrum disorder.

Eric Rubenstein, Laura Schieve, Chyrise Bradley, Carolyn DiGuiseppi, Eric Moody, Kathleen Thomas, Julie Daniels

Abstract readMulticenter Study
In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
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  4. Review
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  6. Article
  7. Article
  8. Autism medical comorbidities.World journal of clinical pediatrics · 2021
    Article
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  10. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eric RubensteinUniversity of North Carolina-Chapel Hill Gillings School of Global Public Health, Chapel Hill, NC.ORCID 0000-0002-9146-4497
Laura SchieveNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA.
Chyrise BradleyUniversity of North Carolina-Chapel Hill Gillings School of Global Public Health, Chapel Hill, NC.
Carolyn DiGuiseppiColorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO.
Eric MoodyColorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO.
Kathleen ThomasUniversity of North Carolina-Chapel Hill Cecil G. Sheps Center for Health Services Research, Chapel Hill, NC.
Julie DanielsUniversity of North Carolina-Chapel Hill Gillings School of Global Public Health, Chapel Hill, NC.

Funding

Centers for Autism & Develop Disabilities Resarch & Epidemiol:A Case-Cohort StudyU10DD000183 · DD · JOHNS HOPKINS UNIVERSITY · PI FALLIN, M DANIELE · 2006 to 2010
$8.2M
MD CADDRE: Study to Explore Early Development, SEED Phase IIU01DD000746 · DD · JOHNS HOPKINS UNIVERSITY · PI FALLIN, M DANIELE · 2011 to 2015
$7.0M
Component A: NC Study to Explore Early Development Phase 3 (SEED 3)U01DD001205 · DD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DANIELS, JULIE L · 2016 to 2020
$6.4M
POSTDOCTORAL TRAINING IN MENTAL RETARDATION RESEARCHT32HD007489 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Sigan L Hartley · 1995 to 2026
$6.0M
Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI POLLAK, SETH D · 2016 to 2020
$6.0M
National CADDRE Study: Child Development and AutismU10DD000182 · DD · UNIVERSITY OF PENNSYLVANIA · PI PINTO-MARTIN, JENNIFER A · 2006 to 2010
$5.8M
National CADDRE Study: Child Development and AutismU10DD000181 · DD · KAISER FOUNDATION RESEARCH INSTITUTE · PI CROEN, LISA A · 2006 to 2010
$5.6M
Colorado CADDRE: A Case-Cohort StudyU10DD000180 · DD · COLORADO STATE DEPT/PUB HLTH & ENVIRONMT · PI MILLER, LISA ANN · 2006 to 2010
$5.1M
North Carolina Ctr for Autism & Development Disabilities Research & EpidemiologyU10DD000184 · DD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DANIELS, JULIE L · 2006 to 2010
$4.7M
Component A: CADDRE: Study to Explore Early Development (SEED) 3U01DD001210 · DD · UNIVERSITY OF COLORADO DENVER · PI ROBINSON, CORDELIA · 2016 to 2020
$3.8M
Data Coordinating Center for Autism & Other DisabilitiesU01DD000498 · DD · MICHIGAN STATE UNIVERSITY · PI REED, PHILIP L · 2009 to 2011
$2.3M
NCBDD CDC HHS U01 DD000498NCBDD CDC HHS U01 DD000746NCBDD CDC HHS U01 DD001205NCBDD CDC HHS U01 DD001210NCBDD CDC HHS U10 DD000180NCBDD CDC HHS U10 DD000181NCBDD CDC HHS U10 DD000182NCBDD CDC HHS U10 DD000183NCBDD CDC HHS U10 DD000184NICHD NIH HHS T32 HD007489NICHD NIH HHS U54 HD090256
6 · The paper itself

Abstract

Our objective was to estimate prevalence of current or ever use of a gluten free diet (GFD) in children aged 30-68 months with autism spectrum disorder (ASD) and population controls (POP); and to identify characteristics associated with ever having used GFD among children with ASD. We used data from the Study to Explore Early Development (SEED), a multi-site, case-control study of children with ASD. Caregivers reported GFD use by their children through structured questionnaires about diet patterns, gastrointestinal (GI) issues, and ASD-specific treatments. Prevalence was estimated and compared using log-Poisson regression, adjusting for confounders. In children with ASD, we examined whether child or mother's GI conditions or child's phenotypic traits were associated with ever trying a GFD. In SEED, 71 children with ASD (11.1% prevalence after adjustment) were on a GFD at time of the study and 130 (20.4%) had ever used a GFD, a greater percentage than in POP children (N = 11, 0.9% current use). Of current users with ASD, 50.7% had a dietary intervention that was prescribed by a medical professional. Among children with ASD, child GI conditions and developmental regression were positively and independently associated with having ever used a GFD. Current use and ever use of a GFD were prevalent in children with ASD identified in SEED. GFD usage was associated with GI issues and child phenotype. Clinicians may consider advising parents on how best to use these diets in the context of the child's GI presentation and current scientific knowledge about effectiveness in relation to ASD symptoms. Autism Res 2018, 11: 185-193. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Gluten free diets (GFDs) are commonly used as an alternative therapy for autism spectrum disorder (ASD); however, the effectiveness is still uncertain which makes it important to know who tries this type of diet. We found that one in five preschool aged children with ASD had ever used a GFD. Children with gastrointestinal conditions and developmental regression were more likely to have tried a GFD.

Indexed as

Autism Spectrum DisorderCase-Control StudiesChildChild, PreschoolDiet, Gluten-FreeFemaleGastrointestinal DiseasesHumansMaleParentsPrevalenceSurveys and Questionnairesalternative therapyautism spectrum disordergastrointestinal conditionsgluten free dietprevalence

Identifiers

PMID29155492
PMCPMC5773346

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.