Evidence map›Paper›PMID 29155454›Full record

ReviewImmunology2018

Harnessing the power of regulatory T-cells to control autoimmune diabetes: overview and perspective.

Hua Yu, Ricardo Paiva, Richard A Flavell

Open access · bronzeAbstract readReview
In one paragraph

Review in Immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
7.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
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  9. Review
  10. Article
  11. The Impact of Intestinal Microorganisms and Their Metabolites on Type 1 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022
    Review
  12. Review
  13. Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Hua YuDepartment of Immunobiology, Yale University, New Haven, CT, USA.ORCID 0000-0002-1691-2763
Ricardo PaivaDepartment of Immunobiology, Yale University, New Haven, CT, USA.
Richard A FlavellDepartment of Immunobiology, Yale University, New Haven, CT, USA.
Yale University · USHoward Hughes Medical Institute · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold, GERALD I SHULMAN · 1993 to 2026
$44.0M
Howard Hughes Medical InstituteNCATS NIH HHS UL1 TR001863NIDDK NIH HHS P30 DK045735
6 · The paper itself

Abstract

Type 1 diabetes (T1D) is a T-cell-mediated autoimmune disease resulting in islet β-cell destruction, hypoinsulinaemia and severely altered glucose homeostasis. Although the mechanisms that initiate T1D still remain elusive, a breakdown of immune tolerance between effector T-cells (T

Indexed as

Adoptive TransferDiabetes Mellitus, Type 1Immune ToleranceT-Lymphocytes, RegulatoryAnimalsDiabetes Mellitus, ExperimentalGastrointestinal MicrobiomeInsulin-Secreting CellsInterleukin-2PeptidesReceptors, Interleukin-2IL2 protein, humanInterleukin-2PeptidesReceptors, Interleukin-2clinical applicationsTreg-based immunotherapytype 1 diabetes

Identifiers

PMID29155454
PMCPMC5765377
OpenAlexW2768128404

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.