ArticleJournal of the American Geriatrics Society2018
Periventricular White Matter Hyperintensities and Functional Decline.
Article in Journal of the American Geriatrics Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Trial
- White Matter N-Acylphosphatidylserines (NAPSs) and Myelin Dysfunction in Late-Onset Alzheimer's Disease (LOAD): A Pilot Study.Life (Basel, Switzerland) · 2025Article
- Periventricular radionecrosis after conventionally fractionated radiation for low grade meningiomas.Radiation oncology (London, England) · 2025Article
- IncreasedGeroScience · 2025Article
- Association between periventricular hyperintensity or deep white matter hyperintensity and outcomes of patients with ischemic stroke.Frontiers in neurology · 2025Article
- Alterations in structural integrity of superior longitudinal fasciculus III associated with cognitive performance in cerebral small vessel disease.BMC medical imaging · 2024Article
- Combined Score of Perivascular Space Dilatation and White Matter Hyperintensities in Patients with Normal Cognition, Mild Cognitive Impairment, and Dementia.Medicina (Kaunas, Lithuania) · 2022Article
- Peak ependymal cell stretch overlaps with the onset locations of periventricular white matter lesions.Scientific reports · 2021Article
- Machine learning-based estimation of cognitive performance using regional brain MRI markers: the Northern Manhattan Study.Brain imaging and behavior · 2021Article
- Elevated Circulating Microparticle Subpopulations in Incidental Cerebral White Matter Hyperintensities: A Multimodal Study.Brain sciences · 2021Article
- Differential Effects of Serum Lipoprotein-Associated Phospholipase A2 on Periventricular and Deep Subcortical White Matter Hyperintensity in Brain.Frontiers in neurology · 2021Article
- Predicted disconnectome associated with progressive periventricular white matter ischemia.Cerebral circulation - cognition and behavior · 2021Article
- Cholinergic White Matter Lesions, AD-Signature Cortical Thickness, and Change in Cognition: The Northern Manhattan Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- The association of white matter hyperintensities with stroke outcomes and antiplatelet therapy in minor stroke patients.Annals of translational medicine · 2020Article
- Diastolic Blood Pressure Is Associated With Regional White Matter Lesion Load: The Northern Manhattan Study.Stroke · 2020Article
- Neuroimaging of Cerebral Small Vessel Disease and Age-Related Cognitive Changes.Frontiers in aging neuroscience · 2019Review
- Differential Impact of Plasma Homocysteine Levels on the Periventricular and Subcortical White Matter Hyperintensities on the Brain.Frontiers in neurology · 2019Article
- Characterizing the Penumbras of White Matter Hyperintensities and Their Associations With Cognitive Function in Patients With Subcortical Vascular Mild Cognitive Impairment.Frontiers in neurology · 2019Article
- Prospective Memory Loss and Related White Matter Changes in Patients with Amnestic Mild Cognitive Impairment.Dementia and neurocognitive disorders · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND/
objectivesWe previously showed that global brain white matter hyperintensity volume (WMHV) was associated with accelerated long-term functional decline. The objective of the current study was to determine whether WMHV in particular brain regions is more predictive of functional decline.
designProspective population-based study.
settingNorthern Manhattan magnetic resonance imaging (MRI) study.
participantsIndividuals free of stroke at baseline (N = 1,195; mean age 71 ± 9; n = 460 (39%) male). MEASUREMENTS: Participants had brain MRI with axial T1, T2, and fluid attenuated inversion recovery sequences. Volumetric WMHV distribution across 14 brain regions (brainstem; cerebellum; bilateral frontal, occipital, temporal, and parietal lobes; and bilateral anterior and posterior periventricular white matter (PVWM)) was determined using a combination of bimodal image intensity distribution and atlas-based methods. Participants had annual functional assessments using the Barthel Index (BI) (range 0-100) over a mean of 7.3 years and were followed for stroke, myocardial infarction (MI), and mortality. Because there were multiple collinear variables, least absolute shrinkage and selection operator (LASSO) regression-selected regional WMHV variables most associated with outcomes and adjusted generalized estimating equations models were used to estimate associations with baseline BI and change over time.
resultsUsing LASSO regularization, only right anterior PVWM was found to meet criteria for selection, and each standard deviation greater WMHV was associated with accelerated functional decline of 0.95 additional BI points per year (95% confidence interval (CI) = -1.20 to -0.70) in an unadjusted model, -0.92 points per year (95% CI = -1.18 to -0.67) with baseline covariate adjustment, and -0.87 points per year (95% CI = -1.12 to -0.62) after adjusting for incident stroke and MI.
conclusionIn this large population-based study with long-term repeated measures of function, periventricular WMHV was particularly associated with accelerated functional decline.
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