ArticleIET nanobiotechnology2017
Effect of the polyelectrolyte coating on the photothermal efficiency of gold nanorods and the photothermal induced cancer cell damage.
Article in IET nanobiotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Advances in Photothermal Therapy for Oral Cancer.International journal of molecular sciences · 2025Review
- Progress of Nanomaterials-Based Photothermal Therapy for Oral Squamous Cell Carcinoma.International journal of molecular sciences · 2022Review
- Engineering Gold Nanostructures for Cancer Treatment: Spherical Nanoparticles, Nanorods, and Atomically Precise Nanoclusters.Nanomaterials (Basel, Switzerland) · 2022Review
- Highly efficient polyethylene glycol-functionalised gold nanorods for photothermal ablation of hepatocellular carcinoma cells.IET nanobiotechnology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coating gold nanorods (GNRs) with polyelectrolytes is an effective approach to make them biocompatible for potential use in photothermal treatment (PTT) of cancer. The authors report the effect of coating of the GNRs with polystyrene sulphonate (PSS-GNRs) and PSS plus poly di-allyl di-methyl ammonium chloride (PDDAC-GNRs) on its photothermal conversion efficiency (PTE), cellular uptake and subsequently the photothermal induced cytotoxicity in human oral cancer cells (NT8e). Coating of GNRs with PSS led to decrease in PTE by ∼30% and further coating it with PDDAC led to its increase to similar level, with respect to as- prepared GNRs. The cellular uptake of PDDAC-GNRs in cancer cells was double than that for PSS-GNRs. PTT of cancer cells after treatment with 60 pM of either PDDAC-GNRs or PSS-GNRs resulted in cytotoxicty of ∼90%. At higher concentration of 120 pM, while PSS-GNRs showed no further change, for PDDAC-GNR the photothermal induced cytotoxicity decreased to ∼50%. The broadening of longitudinal surface plasmon peak of PDDAC-GNRs and appearance of dark clusters in cells under bright-field microscope suggested intracellular clustering of PDDAC-GNRs. In conclusion, despite high PTE and cellular uptake of PDDAC-GNRs, its intracellular clustering (due to acidic pH ) adversely affect the PTT of cancer cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.