Evidence map›Paper›PMID 29155309›Full record

ArticleGastroenterology2018

Prognostic Utility of Total

Amit Tirosh, Georgios Z Papadakis, Corina Millo, Dima Hammoud, Samira M Sadowski, Peter Herscovitch, Karel Pacak, Stephen J Marx, Lily Yang, Pavel Nockel and 6 more

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. PSMA PET/CT-Derived Indicators and Outcomes After [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  5. SUV-max ofJournal of neuro-oncology · 2025
    Article
  6. Article
  7. [Cancers · 2025
    Article
  8. Review
  9. Prognostic value ofFrontiers in cardiovascular medicine · 2025
    Article
  10. Role ofFrontiers in medicine · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 4 countries.

Amit TiroshEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Sackler Faculty of Medicine, Tel Aviv University, Israel.
Georgios Z PapadakisPET Imaging Center, National Institutes of Health Clinical Center, Bethesda, Maryland; Institute of Computer Science (ICS), Foundation for Research and Technology Hellas (FORTH), Crete, Greece.
Corina MilloPET Imaging Center, National Institutes of Health Clinical Center, Bethesda, Maryland.
Dima HammoudPET Imaging Center, National Institutes of Health Clinical Center, Bethesda, Maryland.
Samira M SadowskiEndocrine and Thoracic Surgery, University Hospitals of Geneva, Geneva, Switzerland.
Peter HerscovitchPET Imaging Center, National Institutes of Health Clinical Center, Bethesda, Maryland.
Karel PacakNational Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Stephen J MarxNational Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Lily YangEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Pavel NockelEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Jasmine ShellEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Patience GreenEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Xavier M KeutgenEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Department of Surgery, Rush University Medical Center, Chicago, Illinois.
Dhaval PatelEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Naris NilubolEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Electron KebebewEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Department of Surgery, The George Washington University, School of Medicine and Health Sciences, Washington, District of Columbia. Electronic address: kebebewe@mail.nih.gov.
National Cancer Institute · USNational Institutes of Health · USImaging Center · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USNational Institutes of Health Clinical Center · USRush University Medical Center · USUniversity Hospital of Geneva · CH

Funding

Diagnosis, Pathophysiology And Molecular Biology of Pheochromocytoma and ParagangliomaZIAHD008735 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PACAK, KAREL · 2009 to 2024
$28.4M
Therapeutic targets and novel anticancer agents for endocrine cancersZIABC011286 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NILUBOL, NARIS · 2010 to 2025
$16.6M
Project 4: New Approaches to Improving the Effectiveness of Radionuclide Targeted Treatments in Neuroendocrine TumorsP50CA174521 · NCI · UNIVERSITY OF IOWA · PI ODORISIO, THOMAS · 2015 to 2021
$13.2M
EOB Clinical CoreZIDBC011534 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KEBEBEW, ELECTRON · 2014 to 2018
$4.8M
EOB Clinical and Research Fellowship Training ProgramZIEBC011656 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KEBEBEW, ELECTRON · 2015 to 2018
$3.7M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA BC011286Intramural NIH HHS ZID BC011534Intramural NIH HHS ZIE BC011656NCI NIH HHS P50 CA174521
6 · The paper itself

Abstract

BACKGROUND &

aimsSurvival times vary among patients with neuroendocrine tumors (NETs) - even among those with the same site, stage, and grade of primary tumor. This makes it difficult to select treatment for patients with unresectable NETs because some patients can survive decades without treatment.

methodsWe performed a prospective study of 184 patients with NETs (128 [69.6%] with metastases and 11 patients [6.0%] with locally advanced disease) at the National Institutes of Health Clinical Center (Bethesda, MD) from 2013 through 2017. All patients underwent

resultsWe found an inverse correlation between quartiles of

conclusionsIn a prospective study, we demonstrated the prognostic utility of

Indexed as

Positron Emission Tomography Computed TomographyAdultAgedChi-Square DistributionDisease-Free SurvivalDisease ProgressionFemaleGastrointestinal NeoplasmsHumansKaplan-Meier EstimateMaleMarylandMiddle AgedMultivariate AnalysisNeuroendocrine TumorsOrganometallic Compoundsgallium Ga 68 dotatateOrganometallic CompoundsRadiopharmaceuticalsPancreasRadiologySurvivalTumor Size

Identifiers

PMID29155309
PMCPMC5847442
OpenAlexW2770481394

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.