Evidence map›Paper›PMID 29155086›Full record

ArticleToxicology and applied pharmacology2018

Systemic exposure of vinpocetine in pregnant Sprague Dawley rats following repeated oral exposure: An investigation of fetal transfer.

Suramya Waidyanatha, Heather Toy, Natalie South, Seth Gibbs, Esra Mutlu, Brian Burback, Barry S McIntyre, Natasha Catlin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology and applied pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Effect of vinpocetine on embryonic heart rateCurrent research in toxicology · 2023
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Suramya WaidyanathaDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States. Electronic address: waidyanathas@niehs.nih.gov.
Heather ToyBattelle Memorial Institute, Columbus, OH, United States.
Natalie SouthBattelle Memorial Institute, Columbus, OH, United States.
Seth GibbsBattelle Memorial Institute, Columbus, OH, United States.
Esra MutluDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States.
Brian BurbackBattelle Memorial Institute, Columbus, OH, United States.
Barry S McIntyreDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States.
Natasha CatlinDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States.
Battelle · USNational Institute of Environmental Health Sciences · US

Funding

Toxicological Assessments for the National Toxicology ProgramZIAES103316 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WALKER, NIGEL J · 2016 to 2019
$31.9M
NIEHS NIH HHS HHSN273201400027C
6 · The paper itself

Abstract

Vinpocetine is being used worldwide by people of all ages, including pregnant women, for its purported multiple health benefits. However, limited data is available addressing the safety/toxicity of vinpocetine. The National Toxicology Program conducted studies to examine potential effects of vinpocetine on the developing rat. Disposition data is helpful to put the fetal findings into context and provide information on the potential risk for humans. The current study reports the systemic exposure and toxicokinetic (TK) parameters of vinpocetine and metabolite, apovincaminic acid (AVA), in pregnant Harlan Sprague Dawley rats, fetuses and amniotic fluid following oral gavage exposure of dams to 5 and 20mg/kg vinpocetine from gestational day 6 to 18. Vinpocetine was absorbed rapidly in dams with a maximum plasma concentration (C

Indexed as

Maternal-Fetal ExchangeAmniotic FluidAnimalsArea Under CurveFemalePregnancyRatsRats, Sprague-DawleyVinca Alkaloidsapovincaminic acidVinca Alkaloidsvinpocetine

Identifiers

PMID29155086
PMCPMC7063504
OpenAlexW2770373579

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.