Evidence map›Paper›PMID 29155052›Full record

ArticleFree radical biology & medicine2018

Characterization of covalent modifications of HDL apoproteins by endogenous oxidized phospholipids.

Detao Gao, Eugene A Podrez

Abstract read
In one paragraph

Article in Free radical biology & medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Effects of superoxide anion attack on the lipoprotein HDL.Molecular and cellular biochemistry · 2023
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Detao GaoDepartment of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States.
Eugene A PodrezDepartment of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States. Electronic address: podreze@ccf.org.
Cleveland Clinic Lerner College of Medicine · US

Funding

Structure Basis for Talin-mediated Integrin ActivationP01HL073311 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BYZOVA, TATIANA V · 2004 to 2019
$27.4M
Pathophysiological Activities of Oxidized PhospholipidsR01HL077213 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI PODREZ, EUGENE A · 2005 to 2018
$4.5M
Mechanism of atheroprotective function of Akt3 kinaseR01HL126738 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI PODREZ, EUGENE A · 2015 to 2018
$1.6M
LTQ-Orbitrap Velos instrumentS10RR031537 · NCRR · CLEVELAND CLINIC LERNER COM-CWRU · PI WILLARD, BELINDA BELLE · 2011 to 2011
$600k
NCRR NIH HHS S10 RR031537NHLBI NIH HHS P01 HL073311NHLBI NIH HHS R01 HL077213NHLBI NIH HHS R01 HL126738
6 · The paper itself

Abstract

High density lipoprotein (HDL) is cardioprotective, unless it is pathologically modified under oxidative stress. Covalent modifications of lipid-free apoA-I, the most abundant apoprotein in HDL, compromise its atheroprotective functions. HDL is enriched in oxidized phospholipids (oxPL) in vivo in oxidative stress. Furthermore, oxidized phospholipids can covalently modify HDL apoproteins. We have now carried out a systematic analysis of modifications of HDL apoproteins by endogenous oxPL. Human HDL or plasma were oxidized using a physiologically relevant MPO-H

Indexed as

Apolipoprotein A-IApolipoprotein A-IIAtherosclerosisChromatography, LiquidHumansHydrogen PeroxideLipoproteins, HDLOxidation-ReductionOxidative StressPhospholipidsProtein ConformationTandem Mass SpectrometryApolipoprotein A-IApolipoprotein A-IIHydrogen PeroxideLipoproteins, HDLPhospholipidsapoA-IHDLOxidized phospholipid-apoprotein adductOxidized phospholipids

Identifiers

PMID29155052
PMCPMC5767518
OpenAlexW2768596496

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.