Evidence map›Paper›PMID 29154974›Full record

ArticleCancer letters2018

Prostate cancer health disparities: An immuno-biological perspective.

Sanjay Kumar, Rajesh Singh, Shalie Malik, Upender Manne, Manoj Mishra

Abstract read
In one paragraph

Article in Cancer letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. RAB40C regulates SNX9 stabilityCentral-European journal of immunology · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Multiple pathogens and prostate cancer.Infectious agents and cancer · 2022
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Advances of Zinc Signaling Studies in Prostate Cancer.International journal of molecular sciences · 2020
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Sanjay KumarCancer Biology Research and Training Program, Department of Biological Sciences, Alabama State University, Montgomery, AL 36104, USA.
Rajesh SinghDepartment of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Shalie MalikCancer Biology Research and Training Program, Department of Biological Sciences, Alabama State University, Montgomery, AL 36104, USA; Department of Zoology, University of Lucknow, Lucknow 226007, India.
Upender ManneDepartment of Pathology, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Manoj MishraCancer Biology Research and Training Program, Department of Biological Sciences, Alabama State University, Montgomery, AL 36104, USA. Electronic address: mmishra@alasu.edu.
Alabama State University · USMorehouse School of Medicine · USUniversity of Alabama at Birmingham · USUniversity of Lucknow · IN

Funding

Targeted Nanotherapy for prostate cancerSC1CA193758 · NCI · MOREHOUSE SCHOOL OF MEDICINE · PI SINGH, RAJESH · 2014 to 2017
$1.4M
Training and Education ProgramP20CA192973 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MANNE, UPENDER · 2014 to 2017
$767k
Project 2: 2/2 The Alabama State University/UAB Comprehensive Cancer Center PartnershipP20CA192976 · NCI · ALABAMA STATE UNIVERSITY · PI SCISSUM GUNN, KARYN D · 2014 to 2017
$598k
NCI NIH HHS P20 CA192973NCI NIH HHS P20 CA192976NCI NIH HHS SC1 CA193758
6 · The paper itself

Abstract

Prostate cancer (PCa) is the most commonly diagnosed malignancy in males, and, in the United States, is the second leading cause of cancer-related death for men older than 40 years. There is a higher incidence of PCa for African Americans (AAs) than for European-Americans (EAs). Investigations related to the incidence of PCa-related health disparities for AAs suggest that there are differences in the genetic makeup of these populations. Other differences are environmentally induced (e.g., diet and lifestyle), and the exposures are different. Men who immigrate from Eastern to Western countries have a higher risk of PCa than men in their native countries. However, the number of immigrants developing PCa is still lower than that of men in Western countries, suggesting that genetic factors are involved in the development of PCa. Altered genetic polymorphisms are associated with PCa progression. Androgens and the androgen receptor (AR) are involved in the development and progression of PCa. For populations with diverse racial/ethnic backgrounds, differences in lifestyle, diet, and biology, including genetic mutations/polymorphisms and levels of androgens and AR, are risk factors for PCa. Here, we provide an immuno-biological perspective on PCa in relation to racial/ethnic disparities and identify factors associated with the disproportionate incidence of PCa and its clinical outcomes.

Indexed as

Health Status DisparitiesPolymorphism, GeneticAndrogensBlack or African AmericanHumansIncidenceMaleProstatic NeoplasmsReceptors, AndrogenRisk FactorsUnited StatesWhite PeopleAndrogensReceptors, AndrogenHealth disparityImmunotherapyProstate cancer

Identifiers

PMID29154974
PMCPMC5743619
OpenAlexW2770799177

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.