Evidence map›Paper›PMID 29154962›Full record

ArticleThe American journal of pathology2018

A Novel Type 2 Diabetes Mouse Model of Combined Diabetic Kidney Disease and Atherosclerosis.

Karin E Bornfeldt, Farah Kramer, Anna Batorsky, Jinkuk Choi, Kelly L Hudkins, Peter Tontonoz, Charles E Alpers, Jenny E Kanter

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. An Innovative Mitochondrial-targeted Gene Therapy for Cancer Treatment.bioRxiv : the preprint server for biology · 2024
    Article
  4. Review
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Karin E BornfeldtDepartment of Medicine, UW Medicine Diabetes Institute, University of Washington School of Medicine, Seattle, Washington; Department of Pathology, UW Medicine Diabetes Institute, University of Washington School of Medicine, Seattle, Washington.
Farah KramerDepartment of Medicine, UW Medicine Diabetes Institute, University of Washington School of Medicine, Seattle, Washington.
Anna BatorskyDepartment of Pathology, UW Medicine Diabetes Institute, University of Washington School of Medicine, Seattle, Washington.
Jinkuk ChoiDepartment of Pathology, University of California, Los Angeles, California; Department of Laboratory Medicine, University of California, Los Angeles, California; Molecular Biology Institute, University of California, Los Angeles, California.
Kelly L HudkinsDepartment of Pathology, UW Medicine Diabetes Institute, University of Washington School of Medicine, Seattle, Washington.
Peter TontonozDepartment of Pathology, University of California, Los Angeles, California; Department of Laboratory Medicine, University of California, Los Angeles, California; Molecular Biology Institute, University of California, Los Angeles, California.
Charles E AlpersDepartment of Pathology, UW Medicine Diabetes Institute, University of Washington School of Medicine, Seattle, Washington.
Jenny E KanterDepartment of Medicine, UW Medicine Diabetes Institute, University of Washington School of Medicine, Seattle, Washington. Electronic address: jenka@uw.edu.
University of Washington · USUniversity of California, Los Angeles · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI Ellen A Schur · 1986 to 2026
$30.4M
Role of Serum Amyloid A in Diabetic Vascular DiseaseP01HL092969 · NHLBI · UNIVERSITY OF WASHINGTON · PI BORNFELDT, KARIN E. · 2008 to 2019
$23.5M
NUCLEAR RECEPTOR SIGNALING PATHWAYS IN ATHEROGENESISR01HL066088 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TONTONOZ, PETER J · 2001 to 2018
$5.4M
HYPERGLYCEMIA, PROTEIN KINASES AND SMOOTH MUSCLE GROWTHR01HL062887 · NHLBI · UNIVERSITY OF WASHINGTON · PI BORNFELDT, KARIN E. · 1998 to 2014
$4.7M
Lipid-Responsive E3 ubiquitin ligases in cholesterol metabolism and atheroscierosisR01HL136618 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TONTONOZ, PETER J · 2018 to 2021
$2.4M
Obesity and Arterial MetabolismR01HL126028 · NHLBI · UNIVERSITY OF WASHINGTON · PI BORNFELDT, KARIN E. · 2015 to 2018
$1.7M
NHLBI NIH HHS P01 HL092969NHLBI NIH HHS R01 HL062887NHLBI NIH HHS R01 HL066088NHLBI NIH HHS R01 HL126028NHLBI NIH HHS R01 HL136618NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK035816
6 · The paper itself

Abstract

Diabetic kidney disease and atherosclerotic disease are major causes of morbidity and mortality associated with type 2 diabetes (T2D), and diabetic kidney disease is a major cardiovascular risk factor. The black and tan, brachyury (BTBR) mouse strain with leptin deficiency (Lep

Indexed as

AnimalsAtherosclerosisCholesterolDependovirusDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Diabetic NephropathiesDisease Models, AnimalDyslipidemiasGenetic VectorsMaleMice, Inbred C57BLMice, ObeseReceptors, LDLCholesterolReceptors, LDL

Identifiers

PMID29154962
PMCPMC5785558
OpenAlexW2768389875

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.